The Specialized Animal Resources Core

摘要 专业动物资源核心 专业动物资源核心的目的是提高个人调查人员的能力 进行与视觉相关的研究，包括转基因动物的产生和特征。 专业动物资源核心的具体目标如下：1)保持和繁殖遗传- 为VSRC调查人员修改小鼠品系；2)为调查人员提供实时的菌落管理数据 这样他们就可以相应地计划和进行实验；3)与分子管理人员密切合作 生物学和基因分型核心，确保及时对产生的小鼠品系进行基因分型；4)帮助调查人员 在动物活着的时候使用非侵入性方法评估视网膜结构和视觉功能，并5)促进 视觉科学研究人员之间的合作，通过提供访问最先进的设备和 专业知识。核心的资源和经验丰富的人员将使个人调查人员能够 以经济高效的方式更快地培育转基因小鼠品系。核心还将提供 彻底了解由特定突变和基因突变引起的小鼠眼部表型的研究人员 潜在的分子过程。

ABSTRACT The Specialized Animal Resources Core The purpose of the Specialized Animal Resources Core is to enhance the capabilities of individual investigators to conduct vision-related research, including generation and characterization of genetically-modified animals. The Specific Aims of the Specialized Animal Resources Core are as follows: 1) to maintain and breed genetically- modified mouse lines for VSRC investigators; 2) to provide investigators with real time colony management data so they can plan and conduct experiments accordingly; 3) to closely work with the Manager of the Molecular Biology and Genotyping Core to ensure a timely genotyping of the generated mouse lines; 4) to help investigators assess retinal structure and visual function using noninvasive methods while animals are alive, and 5) to promote collaborations among vision science researchers by providing access to state-of-the art equipment and expertise. The Core’s resources along with highly experienced personnel will enable individual investigators to generate genetically modified mouse lines faster and in a cost-efficient manner. The Core will also provide investigators with a thorough understanding of the mouse ocular phenotypes caused by specific mutations and the underlying molecular processes.