Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.

项目摘要 国际小鼠表型鉴定联盟（IMPC）是生物医学研究的重要资源 为具有很少或未知功能的基因提供新的基因-表型关联， 成千上万的机制研究，并提供与基因组，表型和人类疾病的整合- 提供相关信息，以更好地了解罕见和常见疾病的根本原因， 疾病该项目旨在通过以下方式提高资源的公平性和可信度： * 改进资源鉴定，重点是生物技术生产的实际模式生物。 财团 ●通过发布IMPC知识图谱，提高资源的曝光率和采用率 ●开发概念验证，以获取长期可持续性的成本指标

PROJECT SUMMARY The International Mouse Phenotyping Consortium (IMPC) is a critical resource for biomedical research providing novel gene-phenotype associations for genes with little or no known function, supplying strains for thousands of mechanistic studies and delivering integration with genomic, phenomic and human disease- relevant information providing improved understanding into the underlying causes of rare and common disease. This project aims to improve the FAIR-ness and TRUST-worthiness of the resource by: ● Improving resource identification with a focus on the actual model organisms produced by the consortium ● Increasing the exposure and adoption of the resource by publishing an IMPC knowledge graph ● Developing a proof of concept to capture cost metrics for long-term sustainability