22nd Liver Sinusoid Meeting

摘要 此R13应用程序请求国际肝窦学会支持第22届肝窦会议 肝窦研究(ISCHS)将于2024年4月24-26日在香港大学医学院举行 伊利诺伊州的芝加哥分校。申请要求NIAAA和NIDDK为学员的参与提供支持 和非资助的早期调查人员(ESI)。肝窦会议的目标是汇聚一个 国际多学科科学家小组，包括现有和新的调查人员，任职前和任职后 博士生，他们对常见的问题感兴趣：1)肝窦状肝细胞和他们的 串扰，有助于酒精相关性肝病(AALD)的发病和解决，非 酒精性脂肪性肝病(NAFLD)，纤维化，刺激或抑制肝再生，调节 肝脏微循环与肝细胞癌的发生和发展；以及2)新知识 从适用于肝脏研究所有领域的新兴工具，如多重组学、基质组学、生物工程 肝组织、有机物、纳米技术和免疫调节可用于改善肝脏的治疗。 疾病。与会者将展示尖端的、高质量的研究，这些研究开始确定 肝窦内新的分子和细胞相互作用。我们有令人惊讶的差距 对肝脏这一基本功能活动单位的了解；肝窦细胞生物学的进展 对于了解急性酒精性肝病、急性和慢性肝病的细胞学基础至关重要。ISCHS代表 唯一的国际组织，聚集了肝脏生物学和肝细胞交叉领域的领先研究人员 来自世界各地的对话。本次会议将促进和促进：1) 不同国家的人口在遗传和社会背景上不同，他们患有AALD， 急性和慢性肝病；2)国际研究人员之间的资源共享，产生协同效应 和独特的想法；以及3)受训人员在国际一级的互动。加在一起，独一无二的 肝窦环境的会议是一种理想的形式，对潜在的前沿互动 他们的研究对急性酒精性肝病、急性和慢性肝病的发病机制的影响，有助于 协同研究，填补这些空白，推进肝病研究的前沿，以及 预防和治疗方法的发展。

ABSTRACT This R13 application requests support for the 22nd Liver Sinusoid Meeting from the International Society for Hepatic Sinusoidal Research (ISCHS), to be on April 24-26, 2024, in the College of Medicine at the University of Illinois at Chicago. The application requests support from NIAAA and NIDDK for the participation of trainees and non-funded early-stage investigators (ESI). The goal of the Liver Sinusoid Meeting is to bring together an international group of multidisciplinary scientists, including established and new investigators, pre- and post- doctoral trainees, who are interested in the common questions: 1) how hepatic sinusoidal liver cells and their crosstalk, contribute to the pathogenesis and resolution of alcohol-associated liver disease (AALD), non- alcoholic fatty liver disease (NAFLD), fibrosis, stimulation or suppression of liver regeneration, regulation of liver microcirculation, and hepatocellular carcinoma (HCC) onset and progression; and 2) how new knowledge from emerging tools applicable to all areas of liver research, such as multiomics, matrisomics, bioengineered liver tissue, organoids, nanotechnologies, and immunomodulation can be used to improve treatments of liver disease. Participants at the meeting will present cutting-edge, high-quality research, which begins to identify novel molecular and cellular interactions within the liver sinusoid. There are surprising gaps in our understanding of this basic unit of functional activity in the liver; advances in hepatic sinusoidal cell biology are critical to understanding the cellular basis of AALD, acute, and chronic liver disease. The ISCHS represents the only international organization, which gathers leading investigators in liver biology and hepatocellular cross talk from around the world. This meeting will facilitate and promote: 1) international collaborations among different countries with populations differing in their genetics and social backgrounds who suffer from AALD, acute, and chronic liver disease; 2) resource sharing among international investigators, generating synergy and unique ideas; and 3) interaction of trainees at the international level. Taken together, the unique environment of the Liver Sinusoid Meeting is an ideal format for cutting-edge interactions on the potential implications of their research into the pathogenesis of AALD, acute, and chronic liver disease, helping to synergize research that will fill these gaps and advance the frontier of research in liver disease, and development of preventative and therapeutic treatments.