Anti-inflammatory Cell Based Repair of Intervertebral Disc Degeneration

此应用程序是一个多样性补充研究生（博士前）的学生，将 由PI Nadeen Chahine博士就与NIH家长奖相关的研究项目提供咨询。 候选人将是一个新的博士研究生在哥伦比亚大学系 生物医学工程（博士课程）。候选人是一名女性工程师（美国公民），来自 在STEM中代表性不足的种族/族裔群体，由NSF提供的指南定义 和国家卫生研究院关于劳动力多样性的研究。候选人的生物医学工程研究生培训（博士 哥伦比亚大学的生物医学研究计划（项目）增强了生物医学研究人员的多样性。 多样性补充项目将检查基底刚度和椎间融合器的影响。 椎间盘（IVD）衍生基质对促进基于抗炎细胞的退行性变修复的作用 体外诊断多样性补充项目是母R 01研究范围的直接延伸 基于抗炎细胞的IVD变性修复。更好地理解 物理和机械线索调节IVD的基于细胞的修复， 用于治疗椎间盘退变和背痛的治疗进展。

This application is for a diversity supplement for a graduate (pre-doctoral) student that will be advised by the PI Dr. Nadeen Chahine’s on a research project related to this NIH parent award. The candidate will be a new PhD graduate student at Columbia University Department of Biomedical Engineering (PhD program). The candidate is a female engineer (U.S. citizen) from an underrepresented race/ethnic group in STEM, as defined by the guidelines provided by NSF and NIH on workforce diversity. The candidate’s graduate training in Biomedical Engineering (PhD program) at Columbia University enhances the diversity of the biomedical research workforce. The diversity supplement project will examine the effects of substrate stiffness and intervertebral disc (IVD) derived matrices on promoting anti-inflammatory cell based repair of the degenerated IVDs. The diversity supplement project is a direct extension of the scope of the parent R01 studies on anti-inflammatory cell based repair of IVD degeneration. A greater understanding of how physical and mechanical cues regulate cell based repair of the IVD is expected to provide therapeutic advances for treatment of disc degeneration and back pain.