Integrated Musculoskeletal Training Program

综合肌肉骨骼训练计划

• 批准号: 10641414
• 负责人: NADEEN O. CHAHINE
• 金额: $ 9.48万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641414
• 关键词: Musculoskeletal; Training Programs

PROJECT SUMMARY Musculoskeletal diseases and injuries such as osteoarthritis, osteoporosis, tendinopathy, intervertebral disc degeneration and many more continue to be the leading causes of disability worldwide, imposing an enormous socioeconomic burden on the health care system in this country. This era has also ushered in paradigm-shifting scientific revolutions in tissue and regenerative medicine, in vivo and ex vivo disease modeling, sequencing and genomics, high- resolution imaging and biomechanics. These developments at the bench side require multidisciplinary expertise in science, engineering, and medicine to continue to accelerate the trajectory of musculoskeletal research to ultimately address unmet clinical needs at the bedside. However, research training in musculoskeletal research continues to be largely siloed into single discipline approaches and settings. In this application, we propose a new Integrated Musculoskeletal Training Program (IMTP) that brings together world leading musculoskeletal researchers and clinicians at Columbia University with expertise in biomedical engineering, cell and molecular biology, pathology and cell biology, mechanical engineering and innovation. This unique predoctoral training program focuses on integrating the multiple disciplines required for cutting edge research training of the next generation of scientists and engineers in the field. The proposed T32 training program will establish a unique training paradigm in musculoskeletal disease, with the following required training elements: (1) clinical preceptorship in musculoskeletal medicine (orthopaedic surgery, physical medicine and rehabilitation, rheumatology, radiology, etc.), (2) mandatory co-advising by a team consisting of a bioengineer, biologist, and a clinician, (3) innovation and design training for identifying clinical needs and gaps in knowledge / technology, and (4) training in diversity and equity challenges. This T32 training program will provide a unique and timely opportunity to promote, enhance, and deepen multidisciplinary musculoskeletal research by supporting trainees with the skills and the values needed to enter the biomedical research workforce and to solve the complex problems of musculoskeletal disease in the future.

项目概要 肌肉骨骼疾病和损伤，如骨关节炎、骨质疏松症、肌腱病、 椎间盘退变等仍然是导致残疾的主要原因 在世界范围内，给医疗保健系统带来了巨大的社会经济负担 国家。这个时代还迎来了组织和细胞领域范式转变的科学革命。 再生医学、体内和离体疾病建模、测序和基因组学、高 分辨率成像和生物力学。这些板凳方面的发展需要 科学、工程和医学的多学科专业知识继续加速 肌肉骨骼研究的轨迹，最终解决床边未满足的临床需求。 然而，肌肉骨骼研究的研究培训仍然很大程度上局限于单一的 纪律方法和设置。在此应用中，我们提出了一种新的集成 肌肉骨骼训练计划（IMTP）汇集了世界领先的肌肉骨骼 哥伦比亚大学的研究人员和临床医生在生物医学工程、细胞 以及分子生物学、病理学和细胞生物学、机械工程和创新。这 独特的博士前培训计划侧重于整合所需的多个学科 该领域下一代科学家和工程师的前沿研究培训。这 拟议的 T32 训练计划将在肌肉骨骼领域建立独特的训练范例 疾病，具有以下所需的培训内容：（1）肌肉骨骼方面的临床指导 医学（骨科、物理医学和康复、风湿病学、放射学、 等），（2）由生物工程师、生物学家和临床医生组成的团队强制共同提供建议， (3) 识别临床需求和知识差距的创新和设计培训/ 技术，(4) 多样性和公平挑战方面的培训。这个T32培训计划将 提供独特而及时的机会来促进、加强和深化多学科 通过支持受训者进入所需的技能和价值观来进行肌肉骨骼研究 生物医学研究队伍并解决肌肉骨骼疾病的复杂问题 将来。