Climate Change Effects on Pregnancy via a Traditional Food

项目摘要 气候变化对传统粮食系统的影响是土著人健康的重大关切， 对怀孕有未知的影响。母亲的饮食和营养对怀孕有很大的影响 结果，并可能影响母亲和后代的短期和长期健康。然而，在改变的同时， 气候制度对粮食供应和质量的影响有记录， 对怀孕期间食用的食物来源的环境认识不足。某些 不良妊娠结局（APO）与产妇的饮食和营养有关， 民族群体的APO比率总体较高。虽然母亲的饮食和营养已被确定为 作为改善健康差距的一个潜在目标， 土著第一民族母亲怀孕。建议的研究将有助于填补这一关键知识 通过确定气候驱动的环境变化如何影响营养质量， 传统食物来源，以及这可能如何决定土著孕产妇健康结果。我们 在两个特定目标中使用野生太平洋鲑鱼消费的方法调查这一点 美国太平洋西北部地区的民族，因为太平洋鲑鱼是高度敏感， 环境因素，该地区的许多土著第一民族一直在消费 太平洋鲑鱼自古以来就是一种重要的传统食物。在具体目标1中，我们将建立以下影响： 气候变化对太平洋鲑鱼营养成分的影响：1）调查营养指标的历史变化 博物馆标本与历史温度的关系;以及2）营养的实验验证 太平洋鲑鱼暴露在高温下会发生变化。在具体目标2中，我们将确定 太平洋鲑鱼营养成分有助于怀孕结果通过调查太平洋鲑鱼消费 在怀孕的第一民族的个人，并使用超级学习者（机器学习技术）：1）开发一个 模型描述了太平洋鲑鱼特定的营养贡献与母亲饮食之间的关系， 妊娠结局;以及2）将开发的模型应用于操作数据，以测试太平洋 鲑鱼对饮食的特定营养贡献可以影响怀孕结果。这项研究将在 与华盛顿州立大学的社区卫生中心合作，并与区域卫生中心密切合作， 部落和国家。我将有机会使用最先进的核心设施和实验室空间进行这项工作， 我将在我将获得培训的技能和技术方面得到专家的指导。为了丰富我的研究训练，我 我将参加各种研讨会，研讨会系列，和科学会议，以扩大我的专业 网络和准备我过渡到一个独立的科学家。在一起，研究和培训 开发的程序将增强我未来研究的创新潜力，并支持我的长期目标 促进气候复原力和解决脆弱和得不到充分服务的人口的健康差距。

PROJECT SUMMARY Impacts of climate change on traditional food systems is of great concern for Indigenous health and currently has unknown consequences for pregnancy. Maternal diet and nutrition are highly influential in pregnancy outcome and can affect the short- and long-term health of both mothers and offspring. Yet, while changing climate regimes have documented influences on food availability and quality, there is substantial underappreciation for the environments from which foods consumed during pregnancy are sourced. Certain adverse pregnancy outcomes (APOs) have been linked to maternal diet and nutrition, and Indigenous and First Nations groups have overall higher rates of APOs. Though maternal diet and nutrition have been identified as a potential target for improving health disparities, there is a paucity of literature concerning nutrition during pregnancy in Indigenous First Nations mothers. The research proposed will help fill this critical knowledge gap by identifying how climate-driven changes in the environment can influence the nutritional quality of a traditional food source, and how this may determine Indigenous maternal health outcomes. We approach investigating this in two Specific Aims using wild Pacific salmon consumption in pregnant First Nations peoples situated within the Pacific Northwest, USA because Pacific salmon are highly sensitive to environmental factors, and many Indigenous First Nations peoples within this region have been consuming Pacific salmon as a vital traditional food from time immemorial. In Specific Aim 1, we will establish effects of climate change on Pacific salmon nutritional content by: 1) investigating historical changes in nutritional metrics of museum specimen in relation to historical temperatures; and 2) experimental validation of nutritional changes through exposure of Pacific salmon to elevated temperatures. In Specific Aim 2, we will determine if Pacific salmon nutritional content contributes to pregnancy outcome by surveying Pacific salmon consumption in pregnant First Nations individuals, and using super learners (machine learning technology) to: 1) develop a model describing the relationship between Pacific salmon-specific nutritional contributions to maternal diet and pregnancy outcome; and 2) apply the model developed to manipulated data to test if changes in Pacific salmon-specific nutritional contributions to diet can influence pregnancy outcome. The research will be carried out with community health centers at Washington State University, and in close collaboration with regional Tribes and Nations. I will have access to state-of-the-art core facilities and laboratory spaces for this work and will be guided by experts in the skills and techniques that I will gain training in. To enrich my research training, I will be attending various workshops, seminar series, and scientific meetings to expand my professional network and prepare me as I transition to an independent scientist. Together, the research and training program developed will enhance the innovative potential of my future research and support my long-term goal of promoting climate resilience and addressing health disparities in vulnerable and underserved populations.