You and Me Healthy: Testing Protocol

在美国，超过7900万人感染了SARS-CoV-2，超过90万人死亡，但病例 死亡对得不到充分服务的人口的影响尤为严重。疾病早期的新治疗方法可能会改变 大流行的过程，但解决及时检测和药物获取方面的差距的战略至关重要， 最大化影响。社区驱动的干预措施为服务不足的人群提供了检测机会 但需要量身定制，以促进检测和治疗方案以及快速获得 以应对当前的威胁。该提案将评估一个系统化和可扩展的社区- 参与的测试和治疗协议，提供快速访问自我测试，“下一步”指导， 资源，以促进服务不足人群的治疗。我们将评估一个社区参与工具包， 基于我们的专业知识和经验开发的You & Me Healthy Toolkit，以实施基于社区的 在服务水平低下的地区，对COVID-19大流行下一阶段的测试分发和测试和治疗反应 人口。我们的中心假设是，你和我健康工具包将使快速设计和 实施社区驱动的、科学可靠的和有影响力的COVID-19测试， 治疗干预。我们将利用通过以下两个渠道建立的成功伙伴关系和基础设施： 大型国家RADx-UP资助的SARS-CoV 2检测和教育干预（SAY YES！COVID检测， You & Me COVID-Free）;积极登记对社区参与感兴趣的参与者 研究（You & Me Healthy Registry）;与社区参与专家的伙伴关系（社区 校园健康合作伙伴关系）;以及与默塞德150多个当地社区合作伙伴的合作历史 加州县和北卡罗来纳州皮特县少数民族（西班牙裔/拉丁裔/拉丁裔和黑人）比例高，高度贫困 以及医疗保险覆盖率低。我们将应用这个工具包来开发一个快速部署的测试和治疗 通过我们在两个社区的合作伙伴实施的协议，直接应对SARS-CoV 2 感染激增或社区确定的高风险事件超过15个月。我们将检验这一假设 通过以下具体目标：1）评估YMH工具包快速创建有效学术的能力- 社区研究伙伴关系，以促进COVID-19检测的获取; 2）记录家庭检测的结果 使用社区参与的可扩展报告方法; 3）评估测试和治疗方案的能力， 当地资源，以促进及时获得测试，指导，资源链接和治疗。这项工作 将展示一个可推广的工具包的价值，以促进快速和有效的学术社区 建立伙伴关系，以便能够及时进行检测， 应对COVID-19激增或传播威胁。

In the United States, >79 million people have been infected with SARS-CoV-2 and >900,000 died, but cases and deaths disproportionately affect underserved populations. Novel treatments early in disease may transform the pandemic’s course, but strategies that address disparities in timely testing and drug access are essential to maximize impact. Community driven interventions provided access to testing in underserved populations earlier in the pandemic, but need to be tailored to promote test and treat protocols and rapid access to treatment in response to current threats. This proposal will evaluate a systematic and scalable community- engaged test and treat protocol that provides rapid access to self-testing, “next steps” guidance, and local resources to facilitate treatment in underserved populations. We will evaluate a community engagement toolkit, You & Me Healthy Toolkit, developed based on our expertise and experience, to implement community-based test distribution and test and treat responses to the next phase of the COVID-19 pandemic in underserved populations. Our central hypothesis is that that the You & Me Healthy Toolkit will enable rapid design and implementation of a community driven, scientifically robust, and impactful COVID-19 test and treatment intervention. We will leverage successful partnerships and infrastructure established through two large national RADx-UP funded SARS-CoV2 testing and education interventions (SAY YES! COVID TEST, You & Me COVID-Free); an actively enrolling registry of participants interested in community-engaged research (You & Me Healthy Registry); partnerships with community engagement experts (Community Campus Partnerships for Health); and a history of collaboration with 150+ local community partners in Merced County, CA and Pitt County, NC with high proportion minority (Hispanic/Latino/Latinx and Black), high-poverty and low health insurance coverage. We will apply this toolkit to develop a rapid-deployment test and treat protocol implemented through our partners in two communities, launched in direct response to SARS-CoV2 infection surges or at community-identified high-risk events over a 15 month period. We will test this hypothesis through the following specific aims: 1) Evaluate the YMH toolkit ability to rapidly create effective academic- community research partnerships for promoting COVID-19 test access; 2) Document results of at-home tests using a community-engaged scalable reporting approach; 3) Evaluate ability of a test and treat protocol and local resourcing to facilitate timely access to testing, guidance, resource linkage, and therapeutics. This work will demonstrate the value of a generalizable toolkit to promote rapid and effective academic-community partnerships to enable timely testing and access to effective therapeutics in underserved populations in response to COVID-19 surges or transmission threats.