Supplement Year 2: USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub

项目总结 FaceBase联盟的主要目标是通过创造 颅面发育和畸形的全面数据集，以及 将这些数据集传播到更广泛的颅面研究社区。这个 FaceBase 3数据管理和集成中心建立在现有和 成功的科技团队，领导开发、部署、 FaceBase 2数据中心的运营和社区参与。张望 展望FaceBase财团的未来影响，我们面临重大挑战 这包括：(1)如何标注大数据集以支持生物医学研究 社区；(2)如何改善数据集成和促进数据搜索和 (3)如何使用FaceBase的数据来设计研究和 否则将为我们未来的研究提供信息；以及(4)如何将我们的知识从 改善人类头面部健康的动物模型研究。重要的是，这些项目 我们在这里提出的建议旨在解决这些问题，因为我们发展了解剖学-- 基于全面的数据搜索和显示，整合了来自 社区，并促进使用FaceBase数据。为了追求这些目标， 我们提出了以下三个具体目标：具体目标1：创造公平的数据 颅面研究社区的资源库和资源中心。特定目标 2：促进和启用NIDCR支持的对FaceBase的数据贡献 研究人员。具体目标3：通过以下方式培养活跃的FaceBase用户社区 开展外联活动，传播新特征和现有数据集。我们 将创建教育材料，并为下一个 一代头面部研究人员。归根结底，我们提议的项目不会 仅有助于我们全面了解分子调控 头面部发育的机制，但也将展示其他人如何 使用来自FaceBase Hub的数据集开发创新方法 改善人类健康。

PROJECT SUMMARY The major goal of the FaceBase Consortium is to advance research by creating comprehensive datasets of craniofacial development and dysmorphologies, and to disseminate these datasets to the wider craniofacial research community. The FaceBase 3 Data Management and Integration Hub builds on the existing and successful scientific and technical team that has lead the development, deployment, operation and community engagement of the FaceBase 2 data hub. Looking forward to the future impact of the FaceBase Consortium, we face major challenges that include: (1) how to annotate large datasets to empower the biomedical research community; (2) how to improve data integration and facilitate data search and retrieval from the hub; (3) how to use the data from FaceBase to design studies and otherwise inform our future research; and (4) how to translate our knowledge from animal model studies to improve human craniofacial health. Importantly, the projects we propose here are designed to address these issues as we develop anatomy- based comprehensive data search and display, incorporate additional datasets from the community, and promote the usage of FaceBase data. In pursuit of these goals, we propose the following three Specific Aims: Specific Aim 1: Create a FAIR data repository and resource hub for the craniofacial research community. Specific Aim 2: Promote and enable data contributions to FaceBase by NIDCR-supported researchers. Specific Aim 3: Foster a community of active FaceBase users through outreach activities and dissemination of new features and available datasets. We will create educational materials and provide training opportunities for the next generation of craniofacial researchers. Ultimately, our proposed projects will not only contribute to our comprehensive understanding of the molecular regulatory mechanisms of craniofacial development but will also demonstrate how others can use the datasets from the FaceBase Hub to develop innovative approaches to improve human health.