UT StrokeNet Administrative Supplement

项目总结/摘要 在过去的十年里，中风的预防、治疗、康复， 和恢复。然而，在不同人群中进行更多外部有效性试验至关重要。 目前的中风试验受到效率低下的挑战，例如多个机构审查 委员会、试验协议和试验网络，这可能导致招募缓慢或不完整， 质量不稳定，成本高。美国国立卫生研究院中风试验网络（StrokeNet）成立于 解决这些问题的目的。使用中心IRB、主试验协议和 使用单一电子数据采集系统（webDCU），以减少 启动时间和提高数据质量。纳入美国各地的中心旨在增加 参与者数量和多样性。犹他州卫生大学（UUH）是一个非常成功的NIH StrokeNet区域协调中心。犹他州（UT）StrokeNet位于 西部山区，一个由5个州组成的地区，覆盖了美国10%的陆地面积，人口1280万。 居民日益多样化。UT StrokeNet包括9个临床执行站点（CPS），8个 犹他州、科罗拉多和亚利桑那州的成人和1名儿童。在下一个融资期，UT StrokeNet 将继续有效地实施并成功地进行多个成人和儿童 StrokeNet试验使用所有9个研究中心的综合实力。UT StrokeNet旨在提供访问 高质量的，创新的试验，所有西山中风患者，无论患者的性别或 位置. UT StrokeNet将专注于通过提供文化服务来进一步增加少数族裔的招聘。 对其研究团队进行能力培训，并最大限度地为患者提供临床试验 通过使用Telestroke网络，帮助生活在农村和边境地区的人。地方领导 该小组将继续在国家网络委员会任职，为StrokeNet作出贡献 运营UT StrokeNet还将促进当地临床和医学领域的多学科合作， 翻译中风专家（重点关注中风康复），以便提出 创新的试验NINDS和网络。UT StrokeNet将促进教育和职业 博士后临床和转化科学家的发展， 个性化的培训计划，包括体验式学习，可选的课程， 职业和研究指导。通过实现这些目标，UT StrokeNet将有助于 继续发展国家中风试验网络，推进中风研究， 并最终改善西部山区所有人的中风护理。

PROJECT SUMMARY/ABSTRACT The last decade has seen significant advances in stroke prevention, treatment, rehabilitation, and recovery. Yet, more externally valid effectiveness trials with diverse populations are critical. Current stroke trials are challenged by inefficiencies, such as multiple institutional review boards, trial agreements, and trial networks, which can lead to slow or incomplete enrollment, variable quality, and high costs. The NIH Stroke Trials Network (StrokeNet) was founded with the purpose of addressing these issues. The use of a central IRB, Master Trial Agreement and use of a single electronic data capture system (webDCU) were implemented with to reduce start-up times and improve data quality. Inclusion of centers across the US aims to increase participant numbers and diversity. University of Utah Health (UUH) is a highly successful NIH StrokeNet Regional Coordinating Center (RCC). Utah (UT) StrokeNet is centered in the Mountain West, a 5-state region covering 10% of the U.S. landmass with 12.8 million inhabitants of increasing diversity. UT StrokeNet includes 9 Clinical Performing Sites (CPS), 8 adult and 1 pediatric, in Utah, Colorado, and Arizona. In the next funding period, UT StrokeNet will continue to efficiently implement and successfully conduct multiple adult and pediatric StrokeNet trials using the combined strength of all 9 sites. UT StrokeNet aims to provide access to high quality, innovative trials to all Mountain West stroke patients, regardless of patient sex or location. UT StrokeNet will focus on further increasing minority recruitment by providing cultural competency training to its study teams as well as maximizing access to clinical trials for patients living in rural and frontier areas through the use of the Telestroke Network. The local leadership team will continue to serve on national network committees to contribute to StrokeNet operations. UT StrokeNet will also facilitate multi-disciplinary collaborations of local clinical and translational stroke experts (with a strong focus on stroke rehabilitation) in order to propose innovative trials to NINDS and the Network. UT StrokeNet will foster the education and career development of post-doctoral clinical and translational scientists through a focused, individualized training program that includes experiential learning, optional coursework, and career and research mentoring. By achieving these goals, UT StrokeNet will contribute to the continued development of the national stroke trials network, advancement of stroke research, and, ultimately, an improvement of stroke care for all persons in the Mountain West.