New England Regional Coordinating Center for the NINDS Stroke Trials Network

项目总结/摘要 我们建议继续StrokeNet新英格兰区域协调中心（NERCC），一个综合的 大波士顿地区和郊区、马萨诸塞州西部、新罕布什尔州和 佛蒙特州，将作为一个顶级的注册网站和充满活力的贡献者的NINDS中风网络临床试验 网络我们的团队包括大多数主要的学术成人和儿童中风和康复医院 在马萨诸塞州、新罕布什尔州和佛蒙特州。我们的30多家新英格兰医院TeleStroke转诊网络 将扩大我们的潜在招聘，并与即将到来的STEP平台试验特别相关。 所有核心医院都有成功管理和临床试验绩效的良好记录。在 特别是，所有医院都有一个既定的研究基础设施，进行正在进行的临床研究， 中风神经病学与多个学科的强大合作。领导班子由 主要研究者Aneesh Singhal，MD，副PI娜塔莉亚Rost，MD，MPH，研究中心PI，研究中心副PI，和 合作研究者在管理成功的转化临床方面带来了多样化和互补的技能 研究计划，担任审判指导委员会成员，并担任国家领导职务， 他们的领域。我们的团队包括血管神经病学，急诊医学， 神经血管内、神经外科、神经重症监护、神经影像学、卒中康复和临床前 成人和儿童的基础和平移性卒中研究。NERCC团队的优势包括 1)多名研究者和研究中心PI之间密切的个人和专业联系; 2）大患者 人口与地理上多样化的医院设置锚定在一个主要的大都市区; 3）人才 研究中心研究者团队，具有科学成就、创新和受试者招募的跟踪记录， 多中心试验; 4）强大的现有NINDS资助的研究和临床试验管理基础设施， 大多数研究中心; 5）现有的临床研究计划，例如，MGH神经临床研究所， 为波士顿大学和所有哈佛医院服务的NIH临床和转化科学奖项目; 6）在SIREN-NETT、NeuroNEXT、DISCOVERY和MarkVCID试验网络中担任领导角色。总的来说， 在前两个“中风网络”中，NERCC团队表现出了出色的承诺和表现 周期，并有资源，愿景和热情，继续发展新的转化科学， 成功执行NINDS StrokeNet第1、2和3期试验。

PROJECT SUMMARY/ABSTRACT We propose to continue the StrokeNet New England Regional Coordinating Center (NERCC), an integrated team of hospitals in the Greater Boston Area and suburbs, Western Massachusetts, New Hampshire and Vermont that will serve as a top-enrolling site and vibrant contributor to the NINDS StrokeNet Clinical Trials Network. Our group includes most of the major academic adult and pediatric stroke and rehabilitation hospitals in Massachusetts, New Hampshire and Vermont. Our 30+ hospital New England TeleStroke referral network will extend our potential recruitment and become particularly relevant with the upcoming STEP platform trials. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across multiple disciplines. The leadership team composed of Principal investigator Aneesh Singhal, MD, Deputy PI Natalia Rost MD, MPH, Site PIs, Deputy Site PIs, and Co-Investigators bring a diverse and complementary set of skills in managing successful translational clinical research programs, serving as members on trial Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators and site PIs; 2) a large patient population with geographically diverse hospital settings anchored in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure at most of the sites; 5) existing clinical research programs, e.g., MGH Neurological Clinical Research Institute, NIH Clinical and Translational Science Award programs serving Boston University and all Harvard hospitals; and 6) leadership roles in the SIREN-NETT, NeuroNEXT, DISCOVERY and MarkVCID trial networks. Overall, the NERCC Team has demonstrated outstanding commitment and performance in the first two StrokeNet cycles, and has the resources, vision, and enthusiasm to continue to develop new translational science and successfully execute the NINDS StrokeNet Phase 1,2 and 3 trials.