Exercising language: Behavioral and neurophysiological changes after high-intensity exercise training in post-stroke aphasia.

项目摘要/摘要 丧失说话和理解语言的能力对失语症患者和他们的患者来说是毁灭性的 家庭，对生活和情感健康的多个方面产生负面影响。不幸的是，有 失语症患者很少能完全恢复语言技能。需要新的方法来提高 传统疗法，为失语症患者带来更好的结果。 这项拟议的研究试图评估一种有前景的辅助干预措施--体育锻炼的效果。 失语症康复训练。专门为中风后患者设计的一项新的锻炼计划 失语症，将是提供一种安全的、对中风和失语症友好的体育运动干预的手段 获得最佳的身体健康收益。这也将是第一次大规模的失语症研究 考察体育锻炼与传统语言相结合的附加和增强效果 心理治疗。创新的成果衡量标准将不仅包括语言和认知衡量标准，还将包括衡量标准 运动技能以及心理和社会心理结果，将评估体育锻炼的好处。 这项研究的另一个前沿方面是纳入了先进的生理健康措施和 脑血流和脑血管反应性的神经成像指标作为结果指标提供更深层次的 了解运动对中风幸存者的行为和神经影响。 我们将招募110名失语症患者来评估锻炼对行为的多方面影响 与传统的言语语言治疗相结合的单独治疗和身体结果。首先， 体育锻炼对语言、认知、运动以及情绪和心理健康的好处 失语症患者将被确诊。尤其重要的是加强对如何 锻炼可以提高现有言语语言疗法的效果。第二，确定运动是如何诱导的 身体健康的变化与语言的变化有关，认知测量将提供对 成功的运动干预的关键要素。第三，运动性神经血管的评价 通过新的血液供应神经成像工具测量的与行为改善相关的变化将 增进我们对观察到的认知益处的大脑机制的了解。最后，验证了 该项目产生的体育锻炼干预将为寻求帮助的临床医生提供一种新的工具 失语症患者，无论是作为一个独立的计划来增强身体健康、认知和福祉， 或者作为标准言语语言疗法的辅助疗法。最终，这项工作可能会显著改变我们的 思考辅助失语症治疗，使中风和失语症患者受益于非中风和失语症 在这种情况下，传统的手段是一种有前途的、安全的、成本效益高的辅助干预，它可以增强 功能水平，从一般健康到语言，再到社会参与。

Project Summary/Abstract Losing the ability to speak and understand language is devastating for patients with aphasia and their families, negatively impacting multiple aspects of life and emotional well-being. Unfortunately, individuals with aphasia rarely regain their language skills in full. Novel approaches are required that boost the effects of traditional therapies, leading to better outcomes for people with aphasia. The proposed study seeks to evaluate the effects of a promising adjuvant intervention - physical exercise training - on recovery in aphasia. A new exercise program, specifically designed for individuals with post-stroke aphasia, will be the means of providing a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness gains. This will also be the first large scale study in aphasia to systematically examine the additive and enhancing effects of combining physical exercise training with traditional language therapy. Innovative outcome measures will include not only language and cognitive measures but also measures of motor skills and psychological and psychosocial outcomes that will assess the benefits of physical exercise. Another cutting-edge aspect of the study is the inclusion of advanced physiological fitness measures and neuroimaging metrics of blood flow and cerebrovascular reactivity as outcome measures to afford a deeper understanding of the exercise-mediated behavioral and neural effects in stroke survivors. We will recruit 110 individuals with aphasia to evaluate the multifaceted impact of exercise on behavioral and physical outcomes in isolation and in combination with traditional speech-language therapy. First, the benefits of physical exercise for language, cognition, motor, and emotional and psychological well-being in individuals with aphasia will be established. Of particular importance will be an enhanced understanding of how exercise can boost the effects of existing speech-language therapies. Second, determining how exercise-induced changes in physical fitness are related to changes in language and cognitive measures will provide insight into key ingredients of successful exercise interventions. Third, evaluation of the exercise-induced neurovascular changes that relate to behavioral improvements, as measured with novel blood supply neuroimaging tools, will advance our knowledge about the brain mechanisms of the observed cognitive benefits. Finally, the validated physical exercise intervention, resulting from this project, will offer a new tool to clinicians seeking to help individuals with aphasia, either as a free-standing program to enhance physical health, cognition, and well-being, or as an adjunct therapy to standard speech-language therapy. Ultimately, this work could significantly alter our thinking about adjuvant aphasia therapies that can benefit those affected by stroke and aphasia through non- traditional means, in this case, a promising, safe, and cost-efficient adjunct intervention that can enhance all levels of functioning from general health to language to social engagement.