Microbial Impact on NeuroDegeneration in Alzheimer's Dementia: MIND-AD - INCLUDE Admin Suppl

与NOT-OD-22-137一致，提供的行政补充包括 计划，我们计划在年中招募500名18-39岁的唐氏综合症(DS)成年人。 根据构成部分2：“聚集一大群人”，在大西洋地区建立一个群体 一生中患有唐氏综合症的患者进行深度表型分析和共存研究 条件。“我们的联合调查员，肯尼迪·克里格研究所(KKI)的卡彭博士有数据 追溯到大约25年前&gt；500名患有DS的人当时还是孩子(3-17岁)， 现在是成年人了。他还有另外约1,000名成年人(18-35岁)的数据 我们会为了注册的目的重新联系他。从所有500名参与者中，我们将 收集人口统计数据和近亲联系信息，以便在未来的研究中登记， 我们将要求从KKI以外的地方发布医疗记录。将使用此注册表 让参与者参加未来的R01，这与家长奖(R01AG075996；MPIS)类似 Spira&Maher)，将研究常见感染抗体(HSV- 1，HSV-2，CMV，EBV，TOX，SARS-CoV-2)与认知和功能结果， 轻度认知障碍(MCI-DS)与痴呆诊断、血源性AD 生物标记物，以及DS患者加速生物衰老的措施。如果我们 无法从Capone博士以前的参与者中招募500名参与者，我们将扩大 通过邮件列表、诊所、学校、社交媒体和滚雪球，在大西洋中部地区 取样。我们将优先从Capone博士的KKI招募参与者 数据库中有儿童时期的现有医疗条件，精神障碍， 认知/适应功能，以及多导睡眠图的睡眠数据。这部作品是一个补充。 至正在调查的巴尔的摩流行病集水区(ECA)研究的第5.5波 常见感染与认知和功能结局、MCI和痴呆的关系 诊断，基于血液的AD生物标记物，以及加速生物老化的措施 一群人。

Consistent with NOT-OD-22-137, Availability of Administrative Supplements for the INCLUDE Project, we propose to recruit 500 adults with Down syndrome (DS) aged 18-39 in the mid- Atlantic area to create a cohort, per Component 2: “Assembly of a large cohort of individuals with Down syndrome across the lifespan to perform deep phenotyping and study co-existing conditions.” Our Co-Investigator, Dr. Capone, at the Kennedy Krieger Institute (KKI), has data dating back ~25 years on >500 individuals with DS who were then children (3-17yrs) and are now adults. He also has data on an additional ~1,000 who were seen as adults (18-35yr) whom we will recontact for purposes of enrollment. From all 500 participants, we will collect demographic data and next of kin contact information for enrollment in future studies, and we will request releases of medical records from outside of KKI. This registry will be used to enroll participants in a future R01, which, like the parent award (R01AG075996; MPIs Spira & Maher), will investigate the association of antibodies to common infections (HSV- 1, HSV-2, CMV, EBV, TOX, SARS-CoV-2) in blood with cognitive and functional outcomes, mild cognitive impairment (MCI-DS) and dementia diagnoses, blood-based AD biomarkers, and measures of accelerated biological aging in persons with DS. If we cannot recruit 500 participants from among Dr. Capone’s former participants, we will expand through the mid-Atlantic region via mailing lists, clinics, schools, social media, and snowball sampling. We will prioritize recruitment of participants from Dr. Capone’s KKI database with existing data from childhood on medical conditions, psychiatric disorders, cognitive/adaptive function, and sleep data from polysomnography. This work is a supplement to Wave 5.5 of the Baltimore Epidemiologic Catchment Area (ECA) Study, which is investigating associations of common infections with cognitive and functional outcomes, MCI and dementia diagnoses, blood-based AD biomarkers, and measures of accelerated biological aging in that cohort.