Testing the feasibility and preliminary efficacy of a psychological and behavioral intervention to promote physical activity after weight loss surgery

项目总结/摘要 候选人这一行政补充将使菲格博士继续朝着她成为一个 独立调查员，在开发和测试循证干预措施方面具有专业知识， 肥胖症患者的健康和幸福。她迄今为止的成就证明了她作为一个临床医生的承诺。 研究员（39同行评审的出版物），并与额外的培训和指导，她正在接受 通过这项K23奖，她将为减轻肥胖负担和改善 肥胖者的生活质量。 培训计划。菲格博士休完产假回来后将继续她拟议的培训计划， 这将有可能与额外的支持，将释放时间，她专注于培训。这将 包括参加马萨诸塞州总医院正在进行的研究研讨会，定期与她会面 导师，博士霍夫曼，博士桑代克，博士Psaros和博士希利，并继续参与哈佛 Catalyst GRASP计划。她还将按计划参加为期三天的布莱克本肥胖课程 医学，申请ORBIT研究所开发行为治疗以改善健康NIH资助的短 课程在2024年春季，并将采取RCR复习课程。 背景代谢/减肥手术是治疗严重肥胖症最有效的方法， 25%的患者在手术后没有实现持续的有意义的体重减轻。既坚持健康 身体活动和心理健康等行为与维持减肥有关 但高达90%的患者术后不符合体力活动建议。缺乏 心理健康可能导致身体活动水平低，特别是如果患者有负面影响， 与身体活动的情感联系。考虑到这种心理因素的干预措施是 需要改善代谢/减肥手术后挣扎的患者的体力活动依从性 坚持锻炼。 研究战略。为了解决这一差距，这项K23研究使用混合方法设计来适应和测试 积极心理-动机访谈法对手术后患者的体力活动干预 马萨诸塞州总医院体重中心。在完成了对23名患者的定性访谈后， 更好地理解与体力活动相关的情感体验，并进行概念验证试验（N=12）， 根据这些访谈，一项新的适应性干预措施，目前正在进行一项试点随机对照试验。 进展（目标N=58），以测试干预措施的可行性、可接受性和初步疗效。的 拟议的行政补充将使这项试验在Feig博士的研究期间和之后继续有效地进行。 产假，以满足招聘目标，为R 01应用程序奠定基础，以测试 在全面试验中进行干预。

PROJECT SUMMARY/ABSTRACT Candidate. This administrative supplement will allow Dr. Feig to continue toward her path of becoming an independent investigator with expertise in developing and testing evidence-based interventions to improve health and well-being in patients with obesity. Her achievements thus far demonstrate her promise as a clinical researcher (39 peer-reviewed publications), and with the additional training and mentorship she is receiving through this K23 award she will contribute significantly to efforts to reduce the burden of obesity and improve quality of life for those with obesity. Training Plan. Dr. Feig will continue with her proposed training plan after her return from maternity leave, which will be possible with the additional support that will free up for time for her to focus on training. This will include attending ongoing research seminars at Massachusetts General Hospital, meeting regularly with her mentors, Dr. Huffman, Dr. Thorndike, Dr. Psaros, and Dr. Healy, and continuing to participate in the Harvard Catalyst GRASP Program. She will also, as planned, take the three-day Blackburn Course in Obesity Medicine, apply for the ORBIT Institute Developing Behavioral Treatments to Improve Health NIH-funded short course in the spring of 2024, and will take an RCR refresher course. Background. Metabolic/bariatric surgery is the most effective treatment available for severe obesity, yet about 25% of patients do not achieve sustained meaningful weight loss after surgery. Both adherence to health behaviors such as physical activity and psychological well-being are associated with weight loss maintenance after surgery, but up to 90% of patients do not meet physical activity recommendations post-surgery. A lack of psychological well-being may contribute to low levels of physical activity, especially if patients have negative emotional associations with physical activity. Interventions that consider this psychological component are needed to improve physical activity adherence in patients after metabolic/bariatric surgery who are struggling to exercise consistently. Research Strategy. To address this gap, this K23 study is using a mixed methods design to adapt and test a positive psychology-motivational interviewing physical activity intervention in patients post-surgery from the Massachusetts General Hospital Weight Center. After completing qualitative interviews with 23 patients to better understand emotional experiences related to physical activity and a proof-of-concept trial (N=12) of the newly adapted intervention based on these interviews, a pilot randomized controlled trial is currently in progress (target N=58) to test feasibility, acceptability, and preliminary efficacy of the intervention. The proposed administrative supplement will allow this trial to continue to run efficiently during and after Dr. Feig’s maternity leave to meet recruitment goals, laying the groundwork for an R01 application to test efficacy of the intervention in a full-scale trial.