Mechanisms of alpha-hemolysin induced immunoevasion by Staphylococcus aureus

S.金黄色葡萄球菌感染是严重的全球性健康问题。目前，还没有疫苗接种，需要更好地了解对这种细菌的免疫反应。我们将检验S.金黄色葡萄球菌α-溶血素抑制先天免疫细胞向皮肤感染部位的迁移，导致免疫力降低。揭示这一现象背后的机制将为更好地预防和治疗S。金黄色葡萄球菌感染

S. aureus infections represent a serious global health problem. Currently, no vaccination is available demanding a better understanding of the immune response against this bacterium. We will test the hypothesis that S. aureus alpha-hemolysin represses the migration of innate immune cells to sites of cutaneous infection resulting in diminished immunity. Unraveling the mechanism behind this phenomenon will pave the way to better prophylactic and therapeutic measures against S. aureus infections.