Redefining antibiotic resistance plasmid transfer in Staphylococcus aureus

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Multidrug-resistant Golden Staph bacteria are a major health problem. Resistance develops rapidly because bacteria efficiently acquire/share resistance genes. Our discoveries suggest DNA transfer mechanisms are far more diverse and widespread than previously expected and this has wide-reaching implications for numerous pathogenic organisms. This project aims to define the prevalence and key features of each mechanism so treatments can be devised to disrupt the evolution and spread of resistance.