FATTY ACIDS AND TUMOR CHARACTERISTICS IN BREAST CANCER

描述：越来越多的证据支持特定的 个体脂肪酸在乳腺癌发生中的作用多不饱和脂肪 Omega-6(W6)家族的酸，特别是亚油酸，刺激 肿瘤在许多细胞培养和动物模型中的增殖，以及w3脂肪 酸可以抑制细胞的增殖。很少有研究在女性身上解决这一问题， 而其中大多数都受到所采用的措施的限制。建议进行的研究 将汇集两项大型乳腺癌研究与脂肪组织标记物 从美国和欧洲女性中摄取脂肪酸以研究 脂肪酸对肿瘤发生和复发的影响。大豆油的脂肪酸组成 诊断时获得的臀部脂肪样本将提供一个生物标志物 比脂肪摄入量。其中一项研究的分析表明，w3脂肪 酸摄入量和增加w3/w6脂肪的比率对 欧洲女人。这项共有1400名女性参与的研究将增强研究的力量 生物活性脂肪酸在乳腺癌中的作用分析 发生在摄入量范围较大的人群中。此外， 598例6~10年初发乳腺癌初诊病例分析 较早前，将跟进以确定脂肪酸是否储存 影响乳腺癌复发的因素。此外，还计划检查 遗传不稳定性的修饰效应(由P53和 HER-2/neu表达)与雌激素受体状态的关系 生物活性脂肪酸(反映在脂肪组织中)和 这些女性中的乳腺癌患者。他们还将检查是否存在扩散 恶性细胞的能力(Ki-67的表达由肿瘤衡量 标记物MIB-1)受生物活性脂肪组织水平的影响 酸。使用分层分析，调查人员将确定 只有雌激素依赖型肿瘤才会出现这种情况。这个多中心 研究提供了一组女性样本，这些女性的暴露范围比 这是从大多数研究中可以得到的。直接基于脂肪组织的测量 与以前相比，更多的人可以使用脂肪酸商店 在任何一项研究中组装。这将是第一次使用 有足够能力评估先前脂肪酸摄入量的生物标记物 富含w3脂肪酸的饮食对预防乳房的潜在作用 癌症复发。它还处于独特的地位，能够解决 作为决定因素的特定肿瘤特征和脂肪酸 乳腺癌的风险。

DESCRIPTION: Growing evidence supports the involvement of specific individual fatty acids in mammary carcinogenesis. Polyunsaturated fatty acids of the omega-6 (w6) family, particularly linoleic acid, stimulate tumor proliferation in many cell culture and animal models, and w3 fatty acids can suppress proliferation. Few studies have addressed this in women, and most of those are limited by the measures employed. The proposed study will pool two large breast cancer studies with adipose tissue markers of fatty acid intakes from American and European women to study the effects of fatty acids on tumor occurrence and recurrence. Fatty acid composition of gluteal fat specimens obtained at diagnosis will provide a biomarker of specific fat intake. Analyses from one of the studies suggest that w3 fatty acid intakes and increasing ratios of w3 to w6 fat are protective in European women. The pooled study, with 1400 women, will have enhanced power to analyze effects of the biologically active fatty acids on breast cancer occurrence using populations with wide ranges of intake. Additionally, the 598 cases initially diagnosed with incident breast cancer 6-10 years earlier, will be followed-up to determine whether fatty acid stores influence the recurrence of breast cancer. There are also plans to examine the modifying effects of genetic instability (as measured by p53 and HER-2/neu expression), and estrogen receptor status on the relationship between biologically active fatty acids (as reflected in adipose tissue) and breast cancer in these women. They will also examine whether proliferative capacity of malignant cells (Ki-67 expression as measured by the tumor marker MIB-1) is affected by tissue levels of biologically active fatty acids. Using stratified analyses, the investigators will determine whether this is the case only for estrogen dependent tumors. This multi-center study provides a pooled sample of women with a range of exposures wider than that obtainable from most studies. Direct adipose tissue-based measures of fatty acid stores are available from more individuals than previously assembled in any single study. This will be the first study using biomarkers of prior fatty acid intake with adequate power to assess the potential role of diets rich in w3 fatty acids on the prevention of breast cancer recurrence. It is also uniquely positioned to address the importance of specific tumor characteristics and fatty acids in concert as determinants of breast cancer.