SEATTLE BREAST CANCER RESERCH PROGRAM

要求资金，在弗雷德哈钦森癌症研究 中心是一个多学科的乳腺癌研究计划，命名为 西雅图乳腺癌研究项目。该计划的目的将是 鼓励创新的多学科研究， 更好地了解影响正常的因素 乳腺上皮细胞生长和调节，肿瘤促进，和 现有癌症的进展。据推测，这种知识将 导致初级预防的方法，以及改进的方法， 癌前病变和早期肿瘤病变，因此也涉及更好的方法 二级预防和治疗。这些目标将通过以下方式实现： 加强调查人员在多个领域的沟通和协作 通过研讨会、务虚会和联合试点项目， 查明征聘更多调查员的需要 这些学科目前在我们的癌症中心还没有得到充分的代表。 我们中心的一个独特之处是现有人口的优势 资源和研究。另一个主要优势是质量和多样性 现有的基于实验室的研究在细胞和分子 在人类和非人类系统中。通过拟议方案 我们建议的活动，以加强现有的联系和发展新的 在这两个一般研究领域之间架起桥梁的合作研究， 并将这些努力集中在乳腺癌的研究上。我们的指挥能力 在多个确定的人群中进行的研究将提高有效性， 我们的研究结果适用于其他设置。此外，获得 为乳腺癌患者或高危女性服务的诊所将提供 为临床问题提供转化活动的机会。计划和 一个长期维持该计划的机构承诺 描述了

Funds are requested, to develop within the Fred Hutchinson Cancer Research Center a multidisciplinary breast cancer research program, named the Seattle Breast Cancer Research Program. The purpose of the program will be to stimulate innovative multidisciplinary research designed especially to provide a greater understanding of the factors that influence normal mammary epithelial cell growth and regulation, tumor promotion, and progression of existing carcinomas. It is assumed that such knowledge will lead to methods of primary prevention, and to improved methods to identify precancerous and early neoplastic lesions and hence also to better methods of secondary prevention and treatment. These purposes will be achieved by enhancing communication and collaboration among investigators in multiple fields through seminars, retreats, and joint pilot projects, and through the identification of needs for the recruitment of additional investigators from disciplines not adequately represented currently in our cancer center. A unique feature of our center is the strength of existing population-based resources and research. Another major strength is the quality and diversity of existing laboratory-based investigations at the cellular and molecular level in both human and non-human systems. Through the proposed program activities we propose to strengthen existing links and develop new collaborative studies that bridge these two general investigative areas, and focus these efforts on studies of breast cancer. Our ability to conduct studies in multiple defined populations will enhance the validity and applicability of our results to other setting. In addition, access to clinics that serve women with or at high risk of breast cancer will provide opportunities for translational activities to clinical problems. Plans and an institutional commitment to sustain this program on a permanent basis are described.