TONSILS--INDUCTION SITE FOR ORAL IMMUNITY

这项研究假设切除扁桃体会改变水平， 唾液腺分泌物中IgA的特异性。 具体目标1将是 横断面研究，以确定IgA反应的差异， 具有和不具有扁桃体的人类受试者的唾液。 具体目标2将 是一项纵向研究，其中唾液和血清IgA的变化 将在一组儿童中进行前瞻性检查， 和扁桃体切除术后 具体目标3将试图将 扁桃体中IgA抗体分泌细胞的质量和特异性 从儿童身上去除，因为它们与这些人的唾液抗体有关 相同的个体。 该提案的意义在于提供一个 更好地了解扁桃体在唾液分泌中的重要性 反应，并可能提供新的方法，以当地 口腔内的免疫反应。

This study hypothesizes that removal of tonsils will alter the level and specificity of IgA in salivary gland secretions. Specific Aim 1 will be a cross-sectional study to determine the differences in IgA responses in saliva of human subjects with and without tonsils. Specific Aim 2 will be a longitudinal study in which changes in salivary and serum IgA levels will be examined prospectively in a group of children prior to and following tonsillectomies. Specific Aim 3 will attempt to relate the quality and specificity of IgA antibody secreting cells in the tonsils removed from the children as they relate to salivary antibodies in these same individuals. The significance of the proposal is to provide a better understanding of the importance of the tonsils in salivary responses and potentially provide methods for new approaches to local immunization for immune responses in the oral cavity.