MAGNETIC FIELD DEPENDENCE OF ENZYMES AT WEAK FIELDS

描述：本项目的目标是研究 弱直流磁场(0-10高斯)对几种酶反应的影响 在人类生物化学中很重要。血红素酶一氧化氮合酶， 细胞色素P-450和细胞色素C过氧化物酶以及B-12依赖 蛋氨酸合成酶，是相互作用的候选部位 生物系统的0-10高斯磁场。一个磁场 引起一氧化氮水平的变化，(由一氧化氮产生 合酶)，可以改变细胞内钙离子水平，从而改变钙离子 外排率。这将提供分子之间的第一个因果联系 磁场效应和磁效应的细胞或生理终点 实地曝光。这项工作可能会提供一种潜在的重要 有助于全面了解可能对健康造成的影响 环境磁场暴露的影响。假想的机制 相互作用是通过自由基对重组的变化进行的，其中一个 自由基物种是一种金属离子(血红素中的铁，或B12中的钴)。

DESCRIPTION: The objective of this project is to study the influence of weak DC magnetic fields (0-10 gauss) on several enzymatic reactions that are important in human biochemistry. The heme enzymes nitric oxide synthase, cytochrome P-450, and cytochrome C peroxidase, as well as the B-12 dependent enzyme methionine synthase, are candidates for the site of interaction of 0-10 gauss magnetic fields with biological systems. A magnetic field induced change in the level of nitric oxide, (as produced by nitric oxide synthase), could alter intracellular Ca2+ levels and thereby change Ca2+ efflux rates. This would provide the first causal link between molecular magnetic field effects and a cellular or physiological endpoint of magnetic field exposure. This work could provide a potentially important contribution towards a complete understanding of the possible health effects of environmental magnetic field exposure. The postulated mechanism of interaction is through changes in radical pair recombination, where one radical species is a metal ion (iron in heme, or cobalt in B12).