WORK OUTCOME IN DEPRESSION, ANXIETY, AND SCHIZOPHRENIA

该项目的总体目标是评估精神病患者的疗效 关于恢复工作能力的治疗，更广泛地说， 检查工作功能的恢复作为精神病学的一个方面 恢复。到目前为止，我们已经发表了一篇全面的文献综述 关于精神病学的工作成果，汇编了原始数据库 来自18项治疗研究的未分析和未发表的工作结果数据， 并发表了我们对工作成果数据的分析，这些数据来自 关于抑郁症治疗的研究(涉及800多名患者)。这个 拟议中的研究继续我们对抑郁症康复的研究，以及 在我们早期工作的基础上扩展了焦虑领域的新分析 精神障碍和精神分裂症。首先，我们建议回到 抑郁症数据库，以检查抑郁症患者的功能损害和恢复 家庭主妇的角色。因社保局；S聚焦 关于工资工作部门的残疾，我们到目前为止的分析完全 排除了抑郁的家庭主妇。这些女性是唯一一大群 被排除在我们之前的研究之外，约占三分之一 样本中的雌性。包括另外25%左右的 样本中的女性是职业家庭主妇，我们有信息 关于家庭主妇角色对大约一半的抑郁症患者的作用 这些研究中的女性。家庭主妇领域的损害一直是 据报道比工作中更严重，但受控研究 其治疗和病程缺乏。目前的提案还包括 新的研究。在我们的文献回顾中跟进这一建议 精神分裂症的维持性抗精神病药物治疗可能是 与较差的职业结果相关，我们汇编了几个数据 来自主要临床试验的集合，涉及随机分配 精神分裂症患者服用更多与更少的抗精神病药物，现在建议 对它们进行分析以检验这一特定的假设。统一的主题 这些对不同人群的研究之间的联系是，它们与 工作成果作为针对症状的治疗的效果，以及 更广泛地说，这是精神康复的一个重要组成部分。

The overall aim of the project is to evaluate the effects of psychiatric treatments on the restoration of the capacity to work, and, more broadly, to examine restoration of work function as an aspect of psychiatric recovery. To date, we have published a comprehensive literature review on work outcomes in psychiatry, compiled original databases with unanalyzed and unpublished work outcome data from 18 treatment studies, and published our analyses of the work outcome data from ten of the studies (involving over 800 patients) on treatments of depression. The proposed research continues our studies of recovery in depression, and expands on our earlier work with new analyses in the areas of anxiety disorders and schizophrenia. First, we propose to return to the depression databases to examine functional impairment and recovery in the homemaker role. Because of the Social Security Administration';s focus on disability in the work-for-pay sector, our analyses to date completely excluded depressed homemakers. These women, the only large group that was excluded from our prior study, represent approximately one-third of the females in the samples. Including an additional 25% or so of the women in the samples who were working homemakers, we have information about homemaker role functioning on approximately half of the depressed women in these studies. Impairment in the homemaker domain has been reported to be even more severe than at work, but controlled studies of its treatment and course are lacking. The current proposal also includes new studies. Following up on the suggestion in our literature review that maintenance neuroleptic treatment of schizophrenia might be associated with poorer vocational outcomes, we have compiled several data sets from major clinical trials involving randomized assignment of schizophrenic patients to more versus less neuroleptic, and now propose to analyze them to test this specific hypothesis. The unifying thematic link among these studies of different populations is that they bear on work outcome as an effect of symptomatically-oriented treatments, and more generally as an important component of psychiatric recovery.