PROTEIN METABOLISM IN CHILDREN W/ EDEMATOUS MALNUTRITION & LOWER RESP INFECTION

这项研究验证了全身蛋白质动力学假说 患有水肿性营养不良和急性 感染。13名患有水肿性营养不良和急性 感染(受试者)与14名未感染的儿童进行比较 恢复期早期水肿性营养不良(对照儿童)。蛋白 用预充的恒定静脉注射测定动力学 在吸收后状态下输注[13C]亮氨酸和[15N]尿素。 全身蛋白质合成和分解速率的计算 是基于亮氨酸出现率；亮氨酸出现率 根据尿素的出现速率来判断氧化程度。《缺席》 在急性发作期间蛋白质周转率的预期增加 水肿性营养不良患者的感染提示急性时相蛋白 相应的肌肉、肝脏和其他组织的消耗 身体蛋白质，如白蛋白，也可能有钝化 急性期反应。

This study tested the hypothesis that whole-body protein kinetics remain low in children with edematous malnutrition and acute infection. Thirteen children with edematous malnutrition and acute infection (subjects) were compared with 14 uninfected children with edematous malnutrition early in recovery (control children). Protein kinetics were determined by using a primed, constant intravenous infusion of [13C] leucine and [15N2]urea in the postabsorptive state. Calculations of rates of whole-body protein synthesis and breakdown were based on the rate of leucine appearance; the rate of leucine oxidation was estimated from the rate of urea appearance. The absence of the expected increase in the rate of protein turnover during acute infection in edematous malnutrition implies that acute phase proteins are made with a corresponding depletion of muscle, hepatic, and other body proteins such as albumin, and that there may also be a blunting of the acute phase response .