The Chernobyl Tissue Bank

描述（由申请人提供）：本项目的主要目标是为正在进行和未来的Chemobyl事故健康后果研究提供研究资源（Chemobyl组织库：CTB）。 它旨在通过向世界各地的许多研究人员提供从有据可查的病理标本中提取的多份RNA和DNA，最大限度地提高从小块肿瘤中获得的信息量，并为后代科学家保存这一宝贵的材料。 它的存在是为了促进对有限生物资源的合作研究，而不是竞争研究。 CTB确保向患者提供尽可能最好的诊断服务，并确保每一个生物样本都获得适当的伦理同意，标本得到适当的记录和采样，生物材料可用于适当的研究。 经国际公认的病理学家同意，对每一个样本的诊断结果提供给进行分子生物学、治疗、流行病学和其他研究的研究小组。 CTB提供了利用资源材料进行的研究所产生的研究数据的档案。 这些数据可能与核事故放射性沉降物暴露风险的预测和评估直接相关。 CTB允许多个研究人员访问相同的材料，允许对相同分子标记的不同技术进行比较，并分析多个分子标记。 它为将来研究其他标记物（尚不清楚）提供了机会。 还有一些类似的项目，从特定的病人群体中收集生物档案。 然而，这些项目很少从一开始就试图整理从所收集的样本中产生的研究数据。 这个档案是不同的，因为它涉及一个相对罕见的肿瘤，其病因是已知的（暴露于放射性碘的沉降物），因此使环境和生理学的相互作用的研究，它是非常有可能的，许多机制参与甲状腺癌是常见的其他癌症。因此，这项资源支持的研究可能对其他组织中的癌症治疗有其他好处。

DESCRIPTION (provided by applicant): The main objective of this project is to provide a research resource (the Chemobyl Tissue Bank: CTB) for both ongoing and future studies of the health consequences of the Chemobyl accident. It seeks to maximize the amount of information obtained from small pieces of tumor by providing multiple aliquots of RNA and DNA extracted from well-documented pathological specimens to a number of researchers worldwide and to conserve this valuable material for future generations of scientists. It exists to promote collaborative, rather than competitive, research on a limited biological resource. The CTB ensures that the best possible diagnostic service is provided to patients and that appropriate ethical consent is obtained for each biological sample, that specimens are properly documented and sampled and that biological materials are available for appropriate research studies. A diagnosis for each sample, agreed by internationally recognized pathologists, is made available to research groups carrying out molecular biological, therapeutic, epidemiological and other studies. The CTB provides an archive of research data generated from research studies carried out using the resource material. This data may have direct relevance to both prognosis and assessment of risk from exposure to radioactive fallout from a nuclear accident. The CTB allows multiple researchers access to the same material, permitting comparison of different techniques for the same molecular marker and analysis of multiple molecular markers. It provides the opportunity for additional markers (as yet unknown) to be studied in the future. A number of similar projects to amass biological archives from specific patient groups exist. However, few of these projects seek, from their outset, to collate research data produced from the samples collected. This archive is different in that it deals with a relatively rare tumor whose a etiology is known (exposure to radio iodine in fallout), therefore enabling study of the interaction of environment and physiology, it is highly likely that many of the mechanisms involved in thyroid carcinogenesis are common to other cancers. The research supported by this resource may therefore have other benefits to the treatment of cancers in other tissues.