20Years of HIV Research: From Discovery to Understanding

描述(申请人提供)：本次会议致力于回顾自1983年首次发现艾滋病毒以来对艾滋病毒发病机制的理解和见解。它包括20年前活跃在该领域的领导者的先锋演讲。他们将就病毒学、免疫学、流行病学和临床科学的未来挑战发表看法。 会议以主旨演讲开始，涵盖了艾滋病毒感染的全球视角以及艾滋病毒复制所涉及的细胞生物学和分子生物学的各个方面。然后，它以循序渐进的方式解决艾滋病毒感染问题，首先是病毒与细胞表面的相互作用，涉及的病毒株(包括艾滋病毒-2)的多样性，以及控制复制的各种细胞内事件。免疫学反应更详细地包括关于胸腺的信息，更重要的是，先天免疫系统和获得性免疫系统的作用。关于HIV发病机制的陈述不仅涉及免疫系统，还涉及身体的其他组织，包括大脑、胃肠道和肾脏。在过去的Keystone会议上，这些话题并没有得到太多关注。机会性感染和恶性肿瘤也被包括在内，作为艾滋病毒发病机制的贡献的一部分。此外，还考虑了从高度暴露的个人获得的信息、基因多态以及男性和女性对艾滋病毒感染的反应差异。辅助蛋白和辅助因子(例如丙型肝炎和庚型肝炎)的作用也将被讨论。 这次会议汇集了几个不同科学和医学领域的杰出研究人员，讨论艾滋病毒感染和疾病的各个方面，包括其他Keystone会议没有详细讨论的几个主题。将鼓励简短的演讲，以便让观众有时间就每个预定的主题进行讨论。这些介绍将使与会者了解和了解需要采取哪些方法来控制艾滋病毒感染本身及其后果。

DESCRIPTION (provided by applicant): This meeting is dedicated to reviewing the understanding and insights on HIV pathogenesis since the initial discovery of the virus in 1983. It includes pioneer lectures from leaders in the field who were active 20 years ago. They will be presenting views on the future challenges in virology, immunology, epidemiology, and clinical science. The conference opens with keynote addresses covering the global perspective of HIV infection and aspects of cell biology and molecular biology involved in HIV replication. It then addresses HIV infection in a step-wise manner beginning with the interaction of the virus with the cell surface, the diversity of viral strains (including HIV-2) involved, and various intracellular events controlling replication. The immunologic responses include, in greater detail, information on the thymus and importantly, the role of the innate as well as adaptive immune systems. The presentations on HIV pathogenesis deal not only with the immune system, but also with other tissues of the body including the brain, gastrointestinal tract, and the kidney. These topics have not been given much attention in past Keystone conferences. Opportunistic infections and malignancies are also covered as part of the dedication to HIV pathogenesis. In addition, information obtained from highly exposed individuals, genetic polymorphisms and differences in response to HIV infection between men and women are considered. The role of accessory proteins and co-factors (e.g. hepatitis C and G) will also be discussed. This conference brings together outstanding researchers in several different scientific and medical fields to address aspects of HIV infection and disease including several topics that have not been considered in great detail by other Keystone conferences. Short talks will be encouraged to allow time for audience discussions on each of the topics scheduled. The presentations will permit attendees to appreciate and to understand what approaches need to be done to control HIV infection itself as well as its consequences.