Evoked Potential Monitor for Traumatic Brain Injury

描述(由申请人提供)：在美国，创伤性脑损伤(TBI)每年导致大约150,000人死亡。据估计，10.3万名幸存者中的大多数人都要接受漫长的医院疗程和严重的后遗症。颅脑损伤给患者及其家人带来了巨大的情感痛苦，每年给国家带来483亿美元的经济负担。TBI的后果是迅速和毁灭性的。迫切需要对这类危重患者进行可靠的持续神经监测。因此，我们的第一阶段目标是研究定量诱发电位(QEP)分析在检测和监测脑外伤后脑损伤演变方面的应用。我们建议基于一种强大的正弦建模算法ESPRIT来开发一种新型的QEP系统。该系统旨在捕获因受伤而引起的信号分量变化。我们将根据与啮齿动物模型中颅内压升高和脑灌流压降低的相关性来评估QEP分析表征急性脑损伤的能力。此外，我们将观察QEP分析预测可扩张性肿块病变引入72小时后测量的神经学结果的能力。如果我们的第一阶段努力是成功的，我们设想第二阶段的努力专注于该技术的临床验证。我们的长期目标是建立QEP分析作为一种神经诊断工具，以改善对脑外伤患者的护理。

DESCRIPTION (provided by applicant): Traumatic Brain Injury (TBI) results in approximately 150,000 deaths per year in the United States. Most of the estimated 103,000 survivors are subjected to a prolonged hospital course and significant sequelae. TBI is associated with significant emotional distress for the patient and their family, and an economic burden of $48.3 billion per year to the nation. The consequences of TBI are rapid and devastating. There is a pressing need for reliable continuous neurological monitoring of such critical patients. Therefore, our Phase I goal is to investigate the use of quantitative Evoked Potential (qEP) analysis to detect and monitor the evolution of brain injury after TBI. We propose to develop a novel qEP system based on a powerful sinusoidal modeling algorithm known as ESPRIT. This system is intended to capture signal component changes due to injury. We will evaluate the ability of the qEP analysis to characterize acute cerebral injury, based on correlation with elevation of intracranial pressure and reduction of cerebral perfusion pressure in a rodent model. Further, we will observe the ability of qEP analysis to prognosticate the neurological outcome measured 72-hours after the introduction of an expansible mass lesion. If our Phase I effort is successful, we envision a Phase II effort focused on clinical validation of the technology. It is our long-term goal is to establish qEP analysis as a neurodiagnostic tool for improving the care of TBI victims.