Automated LV Wall Thickness in 3D by Ultrasound

描述(由申请人提供)： 我们的总体目标是通过在临床实践中提供定量的心脏测量来改善患者护理。我们以前在快速准确地从超声心动图确定左心室(LV)容量、射血分数和边界位置方面取得了实质性的成功。这项技术将被修改和推广，以更准确地确定区域壁厚。该过程利用测量到的正常和疾病人体心室几何形状变化的知识库，从超声心动图图像中快速、准确地重建患者的三维(3D)心室表面。简而言之，该方法是捕获具有已知位置和方向的2D超声心动图，使用带有测量表面目录的优化程序在3D中检测这些图像上的室壁表面边界，并根据这些边界位置或计算的3D表面计算所需的心脏参数。这个第一阶段项目的具体目的是证明通过使用双表面LV形状的知识库来改进壁厚测量的可行性。基于超声波的测量的准确性将通过磁共振成像进行验证。除了准确的室壁厚度，这种LV量化方法还将提供区域形状信息。这个项目将：建立一个由10个病例组成的测试套件，其几何结构由MRI建立。分析双曲面星表拟合法正确估计每种情况下的几何形状的能力。

DESCRIPTION (provided by applicant): Our overall objective is to improve patient care by making quantitative cardiac measurement available in clinical practice. We have previously achieved substantial success in fast and accurate determination of left ventricle (LV) volume, ejection fraction and border location from echocardiograms. This technology will be modified and extended to determine regional wall thickness more accurately. The process uses a knowledgebase of the measured variation in geometry of normal and diseased human cardiac ventricles to rapidly and accurately reconstruct a patient's ventricle surface in three dimensions (3D) from echocardiogram images. In brief the approach is to capture 2D echocardiograms with known positions and orientations, to detect the ventricle surface borders on these images in 3D using in optimization program with a catalog of measured surfaces, and to compute the desired cardiac parameters from these border locations or from the computed 3D surface. The specific intent of this Phase I project is to demonstrate feasibility of improving wall thickness measurement by using a knowledge base of dual surface LV shapes. The accuracy of the measurements based on ultrasound will be verified with magnetic resonance imaging. In addition to accurate wall thicknesses, this approach to LV quantification will also provide regional shape information. This project will: Establish a test suite of 10 cases with geometry established from MRI. Analyze the ability of the dual surface catalog fit method to correctly estimate the geometry of each case.