Cooperative Breast Cancer Tissue Resource (CBCTR)

描述(由申请人提供) 具体目标 合作乳腺癌组织资源(CBCTR)是根据美国国家癌症研究所和美国四个地点之间的一项合作协议于1993年开发的，该协议向生物医学研究界提供乳腺癌组织，用于研究肿瘤预后的临床标记物，并评估基于这些标记物的有前景的诊断试验。目前的申请是对CBCTR申请再竞争三年资金的信函请求的回应。 具体地说，这四个机构将单独和共同 1.继续从CBCTR档案中向社区研究人员提供标本。提供的材料将主要以组织微阵列的形式提供，该阵列将数百个病例的样本合并到一到两张幻灯片上。然而，当特定的实验只能用这种材料进行时，CBCTR将保留满足一些个别病例的乳腺癌切片材料请求的能力。 2.继续收集和更新每个地点病例的临床和结果数据，以确保为每个病例提供最准确和最新的材料。这种审查将利用自动化的数据来源，但也可能需要审查相当数量的主要来源：这些妇女的医疗记录。 3.对已被科研人员使用的病例补充CBCTR。CBCTR目前是一项有限的资源，没有通过增加新病例来补充。它被设计成供其客户癌症研究人员使用，但不可避免地被耗尽。另一方面，如果有资金可用，并且国家癌症研究所决定在CBCTR中保留大量和有代表性的乳腺癌混合病例，每个站点可以通过自1993年以来诊断的新病例的累积来补充资源，当时最初的申请得到了资助，此后几乎没有新病例累积。

DESCRIPTION (provided by applicant) Specific Aims The Cooperative Breast Cancer Tissue Resource (CBCTR) was developed, starting in 1993, in response to a cooperative agreement between the National Cancer Institute and four sites in the United States to provide breast cancer tissue to the biomedical research community for the study of clinical markers of tumor prognosis and the evaluation of promising diagnostic tests based on these markers. The current application is a response to a Letter Request for Applications for Recompetition of the CBCTR for a further three years of funding. Specifically, these four institutions individually and together will 1. Continue the provision of specimens to researchers in the community from the files of the CBCTR. The material provided will be mainly in the form of Tissue Microarrays that incorporate specimens from hundreds of cases on one or two slides. The CBCTR will, however, retain the ability to fill requests for sections of breast cancer material from a number of individual cases when the particular experiment can only be done with such material. 2. Continue the collection and updating of clinical and outcome data on each site's cases to assure the most accurate and contemporary material for each case. Such review will exploit automated sources of data but will also likely require review of a considerable number of primary sources: the medical records of these women. 3. Replenish the CBCTR for the cases that have been used by researchers. The CBCTR is currently a finite resource and is not being replenished with the addition of new cases. It has been designed to be used and, inevitably, depleted by its client cancer researchers. On the other hand, if funding becomes available and the National Cancer Institute decides to maintain a large and representative mixture of breast cancers in the CBCTR, each site can replenish the Resource by accrual of new cases diagnosed since 1993, when the original application was funded and after which few new cases were accrued.