HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI

产品说明： 此修订后的RO 1应用程序的主要目标是确定健康状况， 非特异性建筑物相关疾病（NSBRI）的社会经济后果（或 病态建筑综合征）的工人诊断与这种流行的疾病。更 美国一半以上的劳动力现在受雇于室内非工业部门 环境.各种症状和疾病越来越多地报告， 这种非工业室内环境。NSBRI是指一种常见的非特异性 通常与特定建筑物相关的障碍。虽然 客观的生理异常通常不会被注意到，NSBRI可以是 这是一个非常令人不快的问题，也是残疾和失去工作时间的重要原因。 尽管如此，NSBRI已经从临床和医学研究中得到了很少的科学关注。 经济前景。在以下方面进展甚微：1） 诊断标准，2）NSBRI的自然史或临床过程，3） 这一共同和重要职业的社会和经济后果 健康问题，或4）不良后果的预测因素。我们的具体目标 目的1A）使用几种不同的病例识别和分类NSBRI病例 NSBRI的定义目标1 B）确定不同 病例定义和各种结果变量。目标2 A）表征 诊断后的NSBI自然史。目标2 B）确定哪种主机 因素（即年龄、婚姻状况、初始症状）和工作场所因素 (i.e.工作压力、工作环境）与疾病进展有关， 严重性。目标3A）确定NSBRI对社会经济结果的影响 (i.e.工作残疾、就业状况、财务状况）。目标3 B）确定 哪些宿主因素和工作场所因素与更不利的 社会经济成果。总体研究设计为回顾性研究 对在YOEMP中诊断为NSBRI的75例患者进行的纵向随访研究 从1994年到1999年的诊所。一组相似的75名肌肉骨骼患者 年龄、性别和诊断年份匹配的患者将用作 社会经济分析。电话采访将评估症状，一般健康状况， 自诊断以来的功能状态、残疾、压力和社会经济状况 关于NSBRI这项研究应该确定诊断标准，增加我们的 了解NSBRI的自然历史和社会经济后果， 以及识别与不良结局相关的风险因素。这 信息对于制定干预措施以预防和/或 改善NSBI的不良后果。

DESCRIPTION: The primary goal of this revised RO1 application is to determine the health and socioeconomic consequences of nonspecific building-related illness (NSBRI) (or sick building syndome) in workers diagnosed with this prevalent disorder. More than half of the U.S. workforce is now employed in indoor nonindustrial environments. Various symptoms and illnesses have increasingly been reported in such nonindustrial indoor environments. NSBRI refers to a common nonspecific disorder which is usually associated with a particular building. Although objective physiologic abnormalities are generally not noted, NSBRI can be extremely unpleasant and an important cause of disability and lost work time. Despite this, NSBRI has received scant scientific attention from a clinical and economic perspective. Little progress has been made in establishing: 1) diagnostic criteria, 2) the natural history or clinical course of NSBRI, 3) the social and economic consequences of this common and important occupational health problem, or 4) the predictors of adverse outcomes. Our Specific Aims are: Aim 1 A) Identify and classify NSBRI cases using several different case definitions of NSBRI. Aim 1 B) Determine associations between the different case definitions and the various outcome variables. Aim 2 A) Characterize the natural history of NSBRI following diagnosis. Aim 2 B) Determine which host factors (i.e. age, marital status, initial symptoms) and workplace factors (i.e. job stress, work environment) are associated with disease progression and severity. Aim 3 A) Determine the effect of NSBRI on socioeconomic outcomes (i.e. work-disability, employment status, financial status). Aim 3 B) Determine which host factors and workplace factors are associated with more adverse socioeconomic outcomes. The overall study design will be a retrospective longitudinal follow-up study of 75 patients diagnosed with NSBRI at the YOEMP Clinic from 1994 to 1999. A similar group of 75 musculoskeletal patients matched on age, gender and year of diagnosis will be used as scontrols for the socioeconomic analysis. Phone interviews will assess symptoms, general health, functional status, disability, stress, and socioeconomic status since diagnosis of NSBRI. This study should identify diagnostic criteria, increase our understanding of the natural history and socioeconomic consequences of NSBRI, as well as identify risk factors associated with worse outcomes. This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI.