Validation of an Integrated Heart Rated/Activity Monitor

描述（由申请人提供）：该计划公告的一个主要目标是响应本赠款提案，以“支持研究，以改善身体活动的测量，通过改进的仪器，技术，或统计/分析技术”，用于“一般和不同的人群。“这项探索性/开发性R21拨款申请下提出的工作将涉及验证一种新的身体活动监测仪（PAM），该监测仪是弗吉尼亚大学和巴伦联合公司最近合作开发的。 PAM设备的新功能包括：（1）能够在单个离散的低轮廓设备中同时收集惯性传感器和心率测量数据;以及（2）测量佩戴者质心（CM）的六个自由度（6-DOF）身体轴加速度，这允许完全区分其CM在三维空间中的平移和旋转运动。这种能力转化为比其他商业活动记录仪更准确的活动能量消耗估计。PAM系统还可以精确跟踪身体活动的时间、频率和强度。原始数据和处理后的数据都可以存储在PAM系统存储器中，用于随后离线上传到PC或个人数字助理（PDA），或者经由蓝牙无线通信真实的在线上传。 拟议的第1年工作重点将是在对90名健康成人的回顾性研究中，根据代谢测量系统验证PAM能量消耗估计值和在不同活动强度水平下花费的时间的准确性。PAM系统的精度（即，仪器间和仪器内的可靠性）也将在第1年进行评估。拟议的第2年工作将涉及PAM系统与代谢测量系统在类似受试者人群中的前瞻性验证，以及PAM估计值与适用于现场使用的其他“专业级”活动监测器的估计值的比较。受试者将被测试的身体活动范围从模拟日常生活活动到“最大有氧努力”。 PAM系统具有很强的潜力来影响身体不活动对健康的不利影响，例如心血管疾病、肥胖和2型糖尿病。PAM系统还将有益于睡眠研究、步态研究、疼痛管理、老年稳定性评估和跌倒监测以及ADHD的诊断，仅举几例应用。

DESCRIPTION (provided by applicant): A principle objective of the Program Announcement to which this grant proposal is responsive is to "support research to improve physical activity measurement through improved instruments, technologies, or statistical/analytic techniques" for use in "general and diverse populations." The work proposed under this exploratory/developmental R21 grant application will involve the validation of a new Physical Activity Monitor (PAM) that was recently developed as a collaborative effort by the University of Virginia and Barron Associates, Inc. Novel features of the PAM device include: (1) the ability to collect inertial sensor and heart rate measurement data simultaneously in a single, discreet, low-profile device; and (2) measurement of the six degree-of-freedom (6-DOF) body-axes accelerations of the wearer's center of mass (CM), which allows complete discrimination of the translational and rotational motions of their CM in three-dimensional space. This capability translates into more accurate activity energy expenditure estimates than is possible with other commercial actigraphs. The PAM system also enables accurate tracking of the timing, frequency, and intensity of physical activity. Both raw and processed data can be stored in PAM system memory for subsequent off-line uploading to a PC or personal digital assistant (PDA), or alternatively uploaded on-line in real time, via Bluetooth wireless communications. Focus of the proposed Year 1 effort will be to validate the accuracy of the PAM energy expenditure estimates and time spent at different activity intensity levels against a metabolic measurement system in a retrospective study of 90 healthy adults. Precision of the PAM system (i.e., inter- and intra-instrument reliability) will also be assessed in the Year 1 effort. The proposed Year 2 effort will involve the prospective validation of the PAM system against the metabolic measurement system in a similar subject population, and comparison of PAM estimates with that of other "professional-grade" activity monitors that are suitable for field use. Physical activities on which subjects will be tested range from simulated activities of daily living, to "naximal aerobic effort. The PAM system has strong potential to impact adverse health effects of physical inactivity, such as cardiovascular disease, obesity and type 2 diabetes. The PAM system will also be of benefit in sleep studies gait studies, pain management, geriatric stability assessment and fall monitoring, and diagnosis of ADHD, to name lust a few applications.