Administrative Core

管理核心摘要 拟成立的迷走神经兴奋和解剖链接评估研究中心旨在对迷走神经刺激(VNS)对四个关键系统的影响进行开创性的研究：自主神经系统、心血管系统、免疫系统和代谢系统。这项雄心勃勃的研究范围需要八个主要学术和医疗机构的参与，包括40多名参与研究的关键人员、140多名患者、一个外部咨询委员会(其中包括患者权益倡导者)、NIH指导委员会和其他NIH人员。因此，一个计划周密、组织严密、人员配备齐全的管理核心对于协调众多RESHOVE利益相关者至关重要，这样该中心才能实现其目标，并为新的VNS研究和基于VNS的新疗法产生基础数据。RELAVE的管理核心将由两位来自明尼苏达大学(UMN)的医学科学家领导，他们具有丰富的科学专长和领导多学科团队的丰富经验，他们是自主神经系统专家、明尼苏达州自主神经调节联合会主任John Osborne博士(Revend Director)，以及UMN外科主任、具有代谢组端点干预措施临床试验设计经验的临床研究员和外科医生Sayeed Ikrauddin博士(Revend MPI)。管理核心的主要目标是促进核心和辅助项目之间的互动，以最大限度地提高REPLAY的生产率；协调所有RESPESS会议，包括年度VESPA会议；确保项目/核心绩效指标、NIH和外部小组之间的沟通畅通；以及管理RESPOW预算和财务。

ADMINISTRATION CORE Abstract The proposed Research Evaluating Vagal Excitation and Anatomical Linkages (REVEAL) center aims to conduct groundbreaking research on the effect of vagal nerve stimulation (VNS) on four key systems: the autonomic nervous system, the cardiovascular system, the immune system, and the metabolic system. The ambitious scope of the research requires the participation of eight major academic and medical institutions with over 40 participating key personnel, over 140 patients, an External Advisory Board (which includes patient advocates), and an NIH Steering Committee and other NIH personnel. As such, a well-planned, well-organized, and well- staffed Administration Core is crucial to coordinate the many REVEAL stakeholders so that the center can achieve its goals and produce foundational data for new VNS research and new VNS-based therapies. The Administration Core for REVEAL will be led by two medical scientists from the University of Minnesota (UMN) who have complimentary scientific expertise and extensive experience leading multidisciplinary teams: Dr. John Osborn (REVEAL Director), an expert in the autonomic nervous system and the director of the Minnesota Consortium for Autonomic Neuromodulation, and Dr. Sayeed Ikramuddin (Reveal MPI), Head of the UMN Department of Surgery and a clinical researcher and surgeon with experience in clinical trial design of interventions on metabolomic endpoints. The main goals of the Administration Core are to facilitate interactions between the Cores and Ancillary Projects to maximize REVEAL’s productivity; coordinate all REVEAL meetings, including an Annual VESPA Meeting; ensure clear lines of communication between Project/Core PIs, the NIH, and external groups; and manage the REVEAL budget and finances.