User-friendly Querying of Integrated Biological Database

描述(由申请人提供)： 我们提出的工作旨在通过在使用基于XML的Web技术和数据库/中介技术的计算基础设施中将挖掘、分析、搜索和浏览等额外的科学任务与传统的数据操作任务相结合，来设计一种适合科学家的查询语言。该基础设施将使用户能够针对多个源表达查询，而无需用户明确了解特定于源的细节，包括位置、数据结构以及计算接口和功能。使用户能够提出和执行这样的查询的相同基础设施也将促进用户应用他们的专业知识来过滤、排名和解决查询结果中的不一致。在试点阶段，我们通过以下研究目标实现这些目标： 目标1：设计一种适用于科学任务的用户友好的查询语言。 目标2：设计一个整合科学资源：数据和应用程序以支持科学查询的系统。 试点阶段将确定和解决以生物查询为重点的科学查询的具体问题。如果试验阶段得到资助，调查员将通过研究项目赠款R01寻求对发展的持续支持。继续支持的目的将是开发在试点阶段设计的调解平台。它将包括：支持XML的包装器生成、将XML包装器合并到中介平台，以及测试和评估。一个由计算机科学家、生物学家和医生组成的团队将为该研究项目拨款R01。

DESCRIPTION (provided by applicant): Our proposed work seeks to design a query language adapted to scientists by combining additional scientific tasks such as mining, analyzing, searching, and browsing with traditional data manipulation tasks in a computational infrastructure that uses XML-based Web technology and database/mediation technology. This infrastructure will enable a user to express queries against multiple sources without explicit user knowledge of source-specific details including location, data structure, and computational interfaces and capabilities. The same infrastructure that enables the user to pose and execute such queries will also facilitate users to apply their expertise to filter, rank, and resolve inconsistencies in the query results. In the pilot phase, we achieve these objectives through the following research aims: Aim 1: Design a user-friendly query language adapted to scientific tasks. Aim 2: Design a system that integrates scientific resources: data and applications to support scientific queries. The pilot phase will identify and resolve specific problems to scientific querying focusing on biological queries. Should the pilot phase be funded, the investigator will seek continuing support for development through a research project grant R01. The aims of the continuing support will be the development of the mediation platform designed at the pilot phase. It will include: XML Enabled Wrapper Generation, incorporation of XML wrappers into a mediation platform, and testing and evaluation. A team of computer scientists, biologists and physicians will be constituted for the research project grant R01.