Mechanisms of regulating gene expression via selective mRNA transport

在癌症改变的基因表达途径中，关键的一步是核输出mRNA。我们已经证明，信使核糖核酸的输出不是结构性的，而是高度选择性的，可以通过鲜为人知的机制来调节不同的生物过程。本项目旨在剖析通过选择性信使核糖核酸转运调控基因表达的分子机制。这将使选择性信使核糖核酸输出成为癌症生物学的一个新的研究领域。

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms. This project aims to dissect the molecular mechanisms of regulating gene expression via selective mRNA transport. This will establish selective mRNA export as a novel area of research in cancer biology.