Wireless Movement Disorder Monitor

描述（由申请人提供）：目的是设计、构建和临床评估专门针对帕金森病（PD）的无线运动障碍监测仪（WMDM）。影响生活质量的主要PD症状包括震颤、运动迟缓、僵硬和运动障碍。客观量化症状将有助于评估治疗方案的疗效。在家监测症状将使临床医生能够捕捉到复杂的波动模式，以应对治疗方案。第一阶段表明，震颤和运动迟缓的严重程度可以使用一个小的，重量轻，无系绳的手指佩戴系统，利用加速度计和陀螺仪监测。在第二阶段，我们将升级硬件和软件，并完成一项大型临床试验。一个新的无线电和安装设计将提供一个更小，更舒适的无系绳病人单位。升级后的软件界面将包括临床视频、患者数据库和远程数据访问。新的检测算法将纳入运动障碍检测。WMDM将在PD受试者的诊所和家中进行临床试验。我们假设WMDM将捕获与震颤、运动迟缓、僵硬和运动障碍的定性临床评分相关的症状变量。此外，WMDM应成功用于PD受试者的家中，系统接受度较高

DESCRIPTION (provided by applicant): The objective is to design, build, and clinically assess a Wireless Movement Disorder Monitor (WMDM) specifically tailored to Parkinson's disease (PD). Major PD symptoms that affect quality of life include tremor, bradykinesia, rigidity, and dyskinesias. Objectively quantifying symptoms would aid in evaluating efficacy of treatment protocols. Monitoring symptoms at home would allow clinicians to capture complex fluctuation patterns in response to treatment protocols. Phase I illustrated that severity of tremor and bradykinesia could be monitored using a small, lightweight, untethered finger worn system utilizing accelerometers and gyroscopes. During Phase II we will upgrade the hardware and software and complete a large clinical trial. A new radio and mounting design will provide a smaller and more comfortable untethered patient unit. The upgraded software interface will include clinical video, a patient database, and remote data access. New detection algorithms will incorporate dyskinesia detection. The WMDM will be clinically tested both in the clinic and in the homes of PD subjects. We hypothesize that the WMDM will capture symptom variables that correlate to qualitative clinical scoring of tremor, bradykinesia, rigidity, and dyskinesias. In addition, the WMDM should be successfully used in the homes of PD subjects with high system acceptance