CIGTS-2 Optic Disc Reading Center

描述（由申请人提供）：协作性青光眼风险和结局研究（CIGTS-2）是一项前瞻性纵向观察研究，旨在确定降低眼压对预防或延缓由开角型青光眼（OAG）引起的进一步视野丧失或视神经进展的长期影响，这些参与者被招募到协作性初始青光眼治疗研究（CIGTS）。CIGTS-2的视盘阅读中心（ODRC）将通过提供现有CIGTS基线和5年后续立体视盘照片的统一屏蔽解释来支持这项研究的任务。迈阿密大学的研究人员是一个经验丰富的团队，他们自1994年以来一直是高眼压治疗研究的ODRC。

DESCRIPTION (provided by applicant): The Collaborative Glaucoma Risks and Outcomes Study (CIGTS-2) is a prospective longitudinal observation study designed to determine the long-term effects of intraocular pressure lowering in preventing or delaying further visual field loss or optic nerve progression due to open angle glaucoma (OAG) in participants recruited into the Collaborative Initial Glaucoma Treatment Study (CIGTS). The Optic Disc Reading Center (ODRC) of CIGTS-2 will support the mission of the study by providing uniform masked interpretation of existing CIGTS baseline and five-year follow-up stereoscopic optic disc photographs. The investigators at the University of Miami are an experienced team, who have been the ODRC for the Ocular Hypertension Treatment Study since 1994. The aims of the CIGTS-2 ODRC are: 1. To establish a protocol for grading optic disc characteristics at baseline and follow-up 2. To evaluate photographic quality 3. To assess development of optic disc progression in a uniform masked manner 4. To re-train and re-certify study photographers 5. To train and certify Primary Readers to grade stereoscopic optic disc photographs for determination of optic disc progression 6. To develop an ODRC infrastructure to receive, log in, track, and archive all stereoscopic optic disc photographs of the CIGTS and CIGTS-2 7. To develop and implement a timely, secure, and reliable data entry and transmittal protocol to transmit databases from the ODRC to the Coordinating Center at the University of Michigan 8. To perform quality assurance procedures at the ODRC to assure reproducible, high quality grading of cup/disc (C/D) ratio and optic disc progression 9. To assist the Coordinating Center to establish a Clinical Assessment Committee protocol to determine if the changes judged by the ODRC are optic disc progression caused by OAG 10. To develop a protocol for the digital archiving of all CIGTS and CIGTS-2 optic disc images and for the construction of a relational database for use by interested researchers in the future 11. To provide the Coordinating Center with optic disc progression rates