Training in Cellular Mechanisms of CVD

描述(由申请人提供)： 培训计划的目标是创造一种环境，让一代心血管科学家(包括医学博士和博士)了解心血管疾病的细胞学基础。这将使学员能够在从基因组学到复杂系统的生理学的连续研究中导航，并使他们能够将这些信息应用于心血管疾病的诊断、治疗和预防。为了实现这一目标，芝加哥两家拥有强大研究和培训记录的主要机构的基础和临床部门已经走到一起，开发了一个综合的翻译培训环境。训练师经过精心挑选，所有直接研究计划都强调分子和细胞生物学与欣赏组织、器官和完整动物的生理学的结合。所有包含的研究项目都有非常明确的 参考临床相关的心血管疾病或治疗，包括高血压和肥厚性心脏病、心力衰竭、遗传性肌病、心肌梗死、动脉硬化性血管疾病和心律失常。该计划的一个重点是无缝的培训环境，在这个环境中，受训者可以在联合项目上与调查团队合作。博士前候选人(3)将在他们在生理学和生物物理学系、药理学系的第一年研究生学习后进入该项目，或者(如果注册了MD/PhD项目)在他们医学院的最初几年之后进入该项目。所有博士前实习生将完成由这些机构建立的教学和研究要求 各部门。博士后实习生(4)将参加根据他们的兴趣和背景安排的两到三年的项目。该计划的一个具体目标是确定和培训基础研究方面的心脏病专家(一旦他们完成了三年的奖学金计划)。这些受训人员将接受类似时期的培训，不受临床义务的限制，并将提供具体的学术和研究经验，以使他们能够竞争入门级研究奖项并开始独立的研究生涯。该计划还支持一系列丰富的心血管生物学研讨会和座谈会。

DESCRIPTION (provided by applicant): The objective of the training program is to create an environment that will provide a generation of cardiovascular scientists (both MD and PhD) with an appreciation of the cellular basis of cardiovascular disease. This will allow trainees to navigate the continuum of investigation from genomics to the physiology of complex systems, and will enable them to apply this information to the diagnosis, treatment, and prevention of cardiovascular disease. To meet this objective, both basic and clinical departments of two major institutions in Chicago with strong research and training track records, have come together to develop an integrated translational training environment. Trainers have been carefully selected and all direct research programs that stress the integration of molecular and cellular biology with an appreciation of the physiolology of tissues, organs, and intact animals. All the research programs encompased have very clear reference to clinically relevant cardiovascular diseases or therapy, including hypertensive and hypertrophic heart disease, heart failure, genetic myopathy, myocardial infarction, arteriosclerotic vascular disease, and arhythmogenesis. An emphasis of the program is the seamless training environment within which trainees can collaborate with teams of investigators on joint projects. Pre-doctoral candidates (3) will enter the program after their initial year of graduate studies in either the Departments of Physiology and Biophysics, Pharmacology, or (if enrolled in the MD/PhD program) after their initial years of medical school. All predoctoral trainees will complete the requirements, both didactic and research, established by these Departments. Post-doctoral trainees (4) will participate in two-three year programs that are structured according to their interests and background. A specific goal of the program is to identify and train cardiologists (once they have completed their three-year program of fellowship) in basic research. These trainees will be exposed to a similar period of training that will be unencumbered by clinical obligations and will provide specific academic and research experiences so as to allow them to compete for entry level research awards and to launch independent research careers. The program also supports a rich series of seminars and a colloquium on cardiovascular biology.