TRAINING GRANT IN NEUROLOGICAL DISORDERS AND STROKE

描述(申请人提供)：据估计，美国有10%的家庭患有发育障碍。迫切需要愿意并能够应用现代研究方法来阐明这些疾病的发病机制和病理生理的研究人员，以便找到新的、更有效的治疗干预措施。我们以费城儿童医院(CHOP)和宾夕法尼亚大学(U Of P)为基地的神经发育障碍跨学科机构博士后培训计划的目的是培训医学博士和博士后研究员，研究重点是导致智力障碍和发育障碍的遗传和获得性障碍。19名导师将参加这一项目的首次竞争性续签；13名主要在CHOP，6名主要在P大学。所有导师都深度参与生物医学研究生教育，并通过相互的研究项目和拨款密切联系在一起。除了有指导的研究培训外，我们的课程还强调对医学博士和博士的临床实践要求，通过P大学研究生课程进行的正式课程工作，以及生物伦理学、生物统计学以及科学写作和演示技能的培训。在我们项目的前4年里，我们接受了8名实习生，其中2名是医学博士，5名是博士，1名是医学博士/博士。到目前为止，在完成我们项目的5人中，2人获得了初级教职，2人在重返学术生涯之前进入了临床培训计划(1人在神经学，1人在神经外科)，1人接受了生物技术公司的职位。另外两名实习生将在来年完成我们的项目；每个人都已获得并接受了医学院助理教授的职位(一名是P大学神经学和儿科专业，另一名是加州大学洛杉矶分校精神病学专业)。我们被批准在头5年每年有4名博士后研究员，并要求在接下来的5年里提供相同水平的资金。

DESCRIPTION (provided by applicant): It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. The aim of our interdisciplinary Institutional Post-doctoral Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Nineteen Mentors will participate in this first competitive renewal of this program; 13 are based primarily at CHOP, and 6 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes a clinical practicum requirement for both MDs and PhDs, formal course work through the U of P Graduate Studies Program, and training in bioethics, biostatistics, and skills in scientific writing and presentation. During the first 4 years of our program, we accepted 8 Trainees, of whom 2 were MDs, 5 PhDs, and 1 and MD/PhD. Of the 5 who have thus far completed our program, 2 have obtained junior faculty positions, 2 have entered clinical training programs (1 in neurology, 1 in neurosurgery) prior to returning to an academic career, and 1 accepted a position in a biotechnology firm. Two additional Trainees will complete our program during the coming year; each has been offered and accepted a medical school assistant professorship (1 in Neurology and Pediatrics, U of P, the other in Psychiatry, UCLA). We were approved for 4 post-doctoral fellows/year during our first 5 years, and request the same level of funding for the next 5 years.