Training Grant in Mechanisms of Vascular Disease

描述(由申请人提供)： 血管疾病机制培训计划的更新将把范德比尔特大学和梅哈里医学院血管生物学多部门研究的相当大的优势和多样性集中在一个连贯的专门培训框架中。参加Vanderbilt的系包括生物化学、生物医学工程、生物科学、癌症生物学、细胞和发育生物学、微生物学和免疫学、分子生理学和生物物理学、病理学、药理学、医学、儿科学，以及皮博迪学院和Meharry微生物学、生物化学和解剖学/生理学的心理学系。将提供七个专门研究领域的培训：(1)蛋白质化学和酶学；(2)生长因子调节/发展；(3)细胞外基质生物学；(4)内皮细胞生物学；(5) 脂蛋白代谢与动脉粥样硬化；(6)心血管调节与疾病心理学；(7)白细胞/红细胞生物学。每个项目将由5-7名积极从事血管生物学相关方面研究的研究人员组成。该计划将为8名博士后、7名博士后(医学博士和/或博士)提供津贴。4名短期实习生。博士前培训将导致获得一个基础科学学科或心理学的学位。论文研究将在一个专业领域与一名培训助学金教员一起进行。博士后培训将主要包括在培训补助金中两名教师导师的指导下进行实验室研究。短期受训人员还将在其中一名导师的指导下主要专注于研究。这项培训将至少持续3个月，可能在一年中的任何时间进行；尽管预计主要在夏季进行。博士后和博士后实习生都将被要求参加由参与教师讲授的课程，血管疾病的细胞和分子基础，以及其他课程，具体取决于候选人的背景。强烈推荐的课程是《科学传播基础》，重点是发展和提高科学交流的书面和口头技能，以及解决科学问题的批判性思维。重点放在手稿和赠款的写作上。学员还将参加血管生物学和正在进行的工作研讨会、年度务虚会和选定的部门研究研讨会。拥有医学博士学位的实习生可以在基础科学学科中寻求博士学位。参与的教职员工的实验室里有充足的空间和最先进的仪器。未来科学家的多学科研究培训对于发现新信息至关重要，这些信息将导致改善心血管疾病的诊断、预防和治疗。

DESCRIPTION (provided by applicant): The renewal of the Training Program in Mechanisms of Vascular Disease will focus the considerable strengths and diversity of multidepartmental research in vascular biology at Vanderbilt University and Meharry Medical College into a coherent framework for specialized training. Participating departments at Vanderbilt include Biochemistry, Biomedical Engineering, Biological Sciences, Cancer Biology, Cell and Developmental Biology, Microbiology & Immunology, Molecular Physiology & Biophysics, Pathology, Pharmacology, Medicine, Pediatrics, and the Psychology Department at Peabody College, and at Meharry Microbiology, Biochemistry and Anatomy/Physiology. Training will be offered in seven specialized areas of research: (1) Protein chemistry and enzymology; (2) Growth factor regulation/development; (3) Biology of the extracellular matrix; (4) Endothelial cell biology; (5) Lipoprotein metabolism and atherosclerosis; (6) Cardiovascular regulation and Psychology of disease, and (7) Leukocyte/red cell biology. Each program will be composed of 5-7 investigators actively pursuing research on related aspects of vascular biology. The program will support stipends for 8 predoctoral, 7 postdoctoral (M.D. and/or Ph.D.) and 4 short-term trainees. Predoctoral training will lead to a degree in one of the basic science disciplines or psychology. Thesis research will be in one of the specialized areas with one of the training-grant faculty. Postdoctoral training will consist primarily of laboratory research under the guidance of two faculty supervisors from the training grant. Short-term trainees will also focus primarily on research under the guidance of one of the preceptors. This training will be for at least 3 months and could occur anytime during the year; although it is expected to be primarily during the summer. Both predoctoral and postdoctoral trainees will be required to participate in the course, Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, and other courses depending on the background of the candidate. A strongly recommended course will be Fundamentals of Scientific Communication, which focuses on development and enhancement of skills in written and oral scientific communications and critical thinking in scientific problem solving. Emphasis is placed on manuscript and grant writing. Trainees will also participate in the Vascular Biology and Work-in-Progress Seminars, the annual retreat, and selected departmental research seminars. Trainees with an M.D. degree may seek a Ph.D. degree in one of the basic science disciplines. Ample space and state-of-the art instrumentation are available in the laboratories of the participating faculty. Multidisciplinary research training of future scientists is critical to discovering the new information that will lead to improved diagnosis, prevention and therapy for cardiovascular.