Training Grant in Clinical Pharmacology

描述（由申请人提供）：本提案是美国国立卫生研究院在梅奥医学院-梅奥诊所资助的临床药理学奖学金培训计划的继续资助请求。临床药理学是研究治疗药物与人之间相互作用的学科。然而，在生物医学领域正在进行的“基因组学蛋白质组学革命”的背景下，临床药理学代表了基础分子遗传学、基因组学和蛋白质组学与合理治疗学之间的重要接口。桥梁学科，如临床药理学，独特地准备利用生物医学的革命，在翻译界面上应用这一新的科学信息，以提供对人类对药物治疗反应的分子基础的理解。然而，利用这一独特机会的能力需要培训新一代的临床药理学家，他们必须彻底扎根于基础分子科学，并能够应用这一科学来研究患者与药物之间的相互作用。在基因组学-蛋白质组学革命的这一点上，像梅奥诊所这样的大型综合学术医疗中心是培训新一代临床药理学家的理想场所。梅奥已经准备好接受这一挑战，因为它的基础科学和临床研究项目是高度整合的，因为它对临床药理学学科的贡献历史悠久，因为梅奥临床药理学培训项目在成功招募和培训希望将生物科学应用于临床药理学的学术医生方面已经有了十年的经验。奖学金培训将强调强大的实验室科学经验，接触临床科学和高度结构化和负责任的指导，这是本提案中描述的梅奥临床药理学奖学金培训计划的核心。

DESCRIPTION (provided by applicant): This proposal is a request for continued funding of the NIH-sponsored Clinical Pharmacology Fellowship Training Program at the Mayo Medical School-Mayo Clinic. Clinical Pharmacology is the study of the interaction between therapeutic agents and humans. However, in the context of the ongoing "Genomics Proteomics Revolution" in biomedical science, Clinical Pharmacology represents an important interface between basic molecular genetic, Genomic and proteomic science and rational therapeutics. Bridge disciplines such as Clinical Pharmacology are uniquely poised to take advantage of the revolution in biomedicine to apply this new scientific information at the translational interface in order to provide an understanding of the molecular basis for human response to drug therapy. However, the ability to take advantage of this unique opportunity will require the training of a new generation of Clinical Pharmacologists who are thoroughly grounded in basic molecular science and who are able to apply that science to study the interaction between patients and drugs. At this point in the Genomics-Proteomics Revolution, large comprehensive, integrated academic medical centers like the Mayo Clinic represent ideal locations for the training of this new generation of Clinical Pharmacologists. Mayo is positioned to accept this challenge because its basic science and clinical research programs are highly integrated, because it has a long history of contribution to the discipline of Clinical Pharmacology and because the Mayo Clinical Pharmacology Training Program has already had a decade of experience in successfully recruiting and training academic physicians who wish to apply biological science to Clinical Pharmacology. Fellowship Training that will emphasize a strong laboratory-based scientific experience, exposure to clinical science and highly structured and accountable mentorship is at the heart of the Mayo Clinical Pharmacology Fellowship Training Program described in this proposal.