Biomolecular Profilometer

描述（由申请人提供）：本SBIR I期可行性研究的目标是创建一种称为BioProfilometer（BioPro）的新型仪器，用于生物分子相互作用的无标记检测。该仪器测量平面芯片的表面轮廓，该平面芯片被设计用于在特定域捕获生物实体。BioPro不包含力测量或动态力反馈功能。因此，它不是一个原子力显微镜（AFM），它将更快，更小，更便宜，比研究级AFM所需的应用。BioPro确实使用了一种微加工设备来快速读取表面上的地形事件。将使用称为ViriChip的亲和捕获方法来测试这种方法用于分子诊断的可行性。ViriChip将病毒颗粒捕获到表面，每个捕获的病毒构成一个事件，应该可以被BioPro检测到。我们预计，这种方法和设备的新奇，简单性和专用性将创造价值，可以转化为商业上可行的产品。

DESCRIPTION (provided by applicant): The goal of this SBIR Phase I feasibility study is to create a novel instrument called a BioProfilometer (BioPro) for label free detection of biomolecular interactions. The instrument measures the surface profile of a planar chip designed to capture biological entities at specific domains. The BioPro does not incorporate force measurement or dynamic force feedback capability. Hence, it is not an atomic force microscope (AFM) and it will be faster, smaller, and less expensive than research-grade AFMs for the desired application. The BioPro does use a microfabricated device to rapidly read topographical events on a surface. The feasibility of this approach for molecular diagnostics will be tested using an affinity capture method called the ViriChip. The ViriChip captures viral particles to a surface, with each captured virus constituting an event that should be detectable by the BioPro. We anticipate that the novelty, simplicity and dedicated nature of this method and device will create value that can be translated into a commercially viable product.