N-HA Coated Dental Implant for Accelerated Early Healing

描述：这个SBIR I期项目旨在证明纳米羟基磷灰石（“n-HA”）涂层钛牙种植体的可行性，使用一种新的电泳沉积（“EPD”）工艺。与表面没有微孔的传统微尺寸透明质酸涂层相比，具有约50nm晶粒尺寸和微孔的透明质酸纳米涂层将提供更高的表面生物活性和血液凝固性，从而显著加快早期骨愈合过程。EPD将用于将n-HA均匀涂覆到钛珠植入物的孔隙中，这是传统热喷涂工艺无法做到的。该项目基于Inframat之前在EPD制造的HA纳米涂层在NIH资助的SBIR项目中用于髋关节置换应用的经验，以及与公司合作伙伴的其他开发项目，展示了HA纳米涂层在无孔Ti6AI4V基板上具有独特的n-HA +微孔表面纹理，将HA涂层与Ti基板的粘附强度提高3倍，体外抗腐蚀能力提高300倍。该计划将：1)优化n-HA分级组成和EPD参数，2)在多孔钛珠状和螺旋形牙种植体上涂覆n-HA， 3)进行HA纳米涂层性能评估。所开发的牙种植体产品预计将优于目前的阳极氧化多孔（钛珠）和等离子喷涂HA涂层螺钉牙种植体，具有加速早期愈合和减少患者疼痛的优点。

DESCRIPTION: This SBIR Phase I program is Aimed at demonstrating the feasibility of nano-hydroxyapatite ("n-HA") coated titanium Dental implants, using a novel electrophoretic deposition ("EPD") process. The HA nanocoating with approximately 50nm grain size and microsized porosities will provide higher surface bioactivity and blood coagulation compared to conventional microsized HA coatings without micropores on the surface leading to a significantly faster early-stage bone healing process. The EPD will be used to uniformly coat n-HA into the pores of Ti beaded implants, which the conventional thermal spray process cannot do. This program builds on the previous experience of Inframat in EPD fabricated HA nano-coatings for hip replacement applications in an NIH funded SBIR program and other development projects with corporate partners, demonstrating HA nano-coatings on a non-porous Ti6AI4V substrate having the unique n-HA plus micropores surface texture, 3X increased HA coating to Ti substrate adhesion strength, and 300X enhanced corrosion resistance in-vitro. The proposed program will: 1) optimize n-HA graded composition and EPD parameters, 2) coat n-HA on porous Ti beaded and screw shaped Dental implants, and 3) perform HA nanocoating property evaluations. The developed Dental implant products are expected to outperform the current anodized porous (Ti beaded) and plasma spray HA coated screw Dental implants with the benefits of accelerated early-stage healing and decreased pain for patients.