Model of stringent response in M.tb

描述(由申请人提供)： 该项目包括将现有模型和实验数据集成到一个严格响应的综合分层模型中。为了实现这一点，我们将组织一个数据库驱动的相关参数和实验数据存储库。这个资料库还将包括相关的模型、理论和已发表的计算。 该项目的一个目的是通过传播现有数据并促进建立和改进综合模型，最大限度地提高现有数据的效益。该项目还将通过帮助识别现有数据的问题和需要更多数据的领域来加强建模和实验之间的反馈。 将开发一个框架，以提供简明和有意义的模型分类。将注意基础数据集、与数据源和数据清理程序的相互参照。数据将根据其性质、来源、实验方法、不确定性、与具体研究问题的相关性进行分类。参数和实验结果将与模型计算交叉参考。

DESCRIPTION (provided by applicant): The project consists of the integration of existing models and experimental data into a comprehensive hierarchical model of the stringent response. To achieve this we will organize a database-driven repository of relevant parameters and experimental data. This repository will also include the relevant models, theories and published calculations. One purpose of this project is to maximize the benefit of existing data by disseminating it and by facilitating the building and improvement of comprehensive models. The project will also enhance feedback between modeling and experiment by helping identify problems with existing data and areas where more data is required. A framework will be developed to provide a concise and meaningful categorization of models. Attention will be given to the underlying datasets, cross-reference with data sources and data cleanup procedures. Data will be categorized by its nature, source, experimental method, uncertainty, relevance to specific research problem. Parameters and experimental results will be cross-referenced with model calculations.