Neural Interactions in Incremental and Episodic Memory

描述（由申请人提供）：该项目的长期目标是了解大脑系统之间的相互作用，从而促进记忆功能的不同方面。几十年的神经心理学和行为学研究强调了不同形式的记忆（如非陈述性记忆与陈述性记忆）之间的分离，每种记忆都由不同的解剖和功能系统支持。这里提出的研究将使用功能成像（fMRI）来开始探索这些系统如何以及何时在健康的大脑中相互作用。这些研究将集中在增量刺激-反应学习（一种非陈述性学习）和情景记忆（一种陈述性记忆）之间的相互作用。增量学习被认为主要依赖于基底神经节（BG），而情景记忆则由内侧颞叶（MTL）支持。拟议的研究计划旨在研究BG和MTL如何在记忆形成过程中相互作用，以及这种相互作用对记忆功能的影响。由此产生的知识有望提高我们对完整大脑中记忆过程的理解，以及对各种神经系统疾病（包括帕金森病和阿尔茨海默病）中记忆障碍的性质的理解。

DESCRIPTION (provided by applicant): The long-term goal of this project is to understand the interaction between brain systems subserving different aspects of memory function. Decades of neuropsychological and behavioral studies have emphasized the dissociation between distinct forms of memory (such as non-declarative vs. declarative memory), each supported by distinct anatomical and functional systems. The studies proposed here will use functional imaging (fMRI) to begin exploring how and when such systems may interact in the healthy brain. The studies will focus on the interaction between incremental stimulus-response learning (a form of non-declarative learning) and episodic memory (a form of declarative memory). Incremental learning is thought to depend critically on the basal ganglia (BG), while episodic memory is supported by the medial temporal lobes (MTL). The proposed research program aims to examine how the BG and MTL interact during memory formation, and the implication of this interaction for memory function. The resulting knowledge is expected to enhance our understanding of memory processes in the intact brain, as well as for understanding the nature of memory impairments in various neurological diseases, including Parkinson's and Alzheimer's disease.