NOVELTY DIFFERENTIALLY MODULATES MEDIAL TEMP LOBE& BASAL GANGLIA MEMORY SYS

新颖性差异调节中温叶

• 批准号: 7358803
• 负责人: Daphna Shohamy
• 金额: $ 0.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358803
• 关键词: NOVELTY; DIFFERENTIALLY; MODULATES; MEDIAL; TEMP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive converging evidence suggests that the medial temporal lobe (MTL) supports rapid conjunctive learning from single episodes, while the basal ganglia (BG) support incremental learning of stimulus-response associations. Recent data have raised the possibility that these neural systems may interact during learning, with other data suggesting that both systems play an important role in processing novelty. Taken together, these findings raise important questions regarding how novelty modulates different forms of memory, and the interaction between them. In this study, we used functional MRI to examine the impact of novelty on MTL and BG dynamics during associative learning and transfer. In this two-phase learning task, subjects first engaged in a concurrent, feedback-based forced-choice discrimination, where they learned to associate faces and scenes. This learning phase was followed by a transfer phase, where subjects were probed to transfer previously learned knowledge to a new context.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。大量的聚合证据表明，内侧颞叶(MTL)支持单次发作的快速合取学习，而基底节(BG)支持刺激-反应关联的增量学习。最近的数据提出了这样一种可能性，即这些神经系统可能在学习过程中相互作用，其他数据表明，这两个系统在处理新奇事物方面都发挥了重要作用。综上所述，这些发现提出了一些重要的问题，即新鲜感如何调节不同形式的记忆，以及它们之间的相互作用。在这项研究中，我们使用功能磁共振来检验新颖性在联想学习和迁移过程中对MTL和BG动力学的影响。在这个分两个阶段的学习任务中，受试者首先进行基于反馈的同步强迫选择辨别，在这个过程中，他们学会了将面孔和场景联系起来。在这个学习阶段之后是一个迁移阶段，在这个阶段，受试者被探索将以前学到的知识转移到一个新的背景下。