ROLE OF GAMMA FIBRINOGEN IN CARDIOVASCULAR DISEASE

纤维蛋白原是公认的心血管疾病（CVD）危险因素。我们的研究小组最近报道了γ prime （gA/g'）纤维蛋白原，一种次要形式的血浆纤维蛋白原，与冠状动脉疾病有关。生化研究表明，与主要纤维蛋白原形式相比，gNg'纤维蛋白原具有不同的凝块结构和不同的凝血和纤溶率。该研究的长期目标是了解gA/g纤维蛋白原在止血、血栓形成和CVD发病机制中的作用。本建议的具体目的是：1。确定gA/g纤维蛋白原与心血管疾病及心血管疾病危险因素之间的关系。2. 目的：探讨gA/g纤维蛋白原对凝血及临床化验的影响。3. 目的：探讨gA/g纤维蛋白原与其他止血因子的关系。临床变量之间的关系将通过横断面研究确定，这是大型队列研究的辅助研究。本研究结果为进一步研究gA/g纤维蛋白原在止血、血栓形成和疾病发病机制中的作用提供了理论基础。

Fibrinogen is a well-established risk factor for cardiovascular diseases (CVD). Our research group has recently reported that gamma prime (gA/g') fibrinogen, a minor form of plasma fibrinogen, is associated with coronary artery disease. Biochemical studies indicate that gNg' fibrinogen has a different clot structure and different coagulation and fibrinolysis rates than the major fibrinogen form. The long-term goals of the proposed research are to understand the role of gA/g' fibrinogen in hemostasis, thrombosis and CVD pathogenesis. The specific aims of this proposal are: 1. To determine the relationships between gA/g' fibrinogen, cardiovascular disease and established risk factors for cardiovascular diseases. 2. To determine the effect of gA/g' fibrinogen on coagulation and on clinical laboratory assays. 3. To determine the relationships between gA/g' fibrinogen and other hemostatic factors. Relationships between clinical variables will be determined using cross-sectional studies, which are ancillary to large cohort studies. The results of the proposed research are necessary to develop a rationale working model for future studies of the role gA/g' fibrinogen in hemostasis, thrombosis and disease pathogenesis.