Mechanisms underlying increased cardiac and renal noradrenaline spillover during heart failure

心力衰竭与交感神经向心脏和肾脏释放的神经递质去甲肾上腺素增加有关。这种神经递质在心脏和肾脏中的水平升高是有害的，并导致心力衰竭患者的存活率降低。该项目将增加我们对控制去甲肾上腺素释放的机制的理解，并可能导致更好的治疗模式，以针对心力衰竭释放的有害增加。

Heart failure is associated with increased release of the neurotransmitter noradrenaline from sympathetic nerves to the heart and the kidney. The raised levels of this neurotransmitter in the heart and the kidney are harmful and lead to reduced survival in heart failure patients. This project will increase our understanding of the mechanisms that control noradrenaline release and may lead to better treatment paradigms to target the detrimental increase in release in heart failure.