OHTS--KRESGE EYE INSTITUTE

说明(调查人员摘要) 这是一份申请成为临床中心的申请书 高眼压治疗研究(OHTS)。完整的详细信息 OHTS基本原理、设计和方法包含在OHTS手册中 程序。本建议书提供了有关该功能的完整文档 Kresge眼科研究所筛查大量高眼压患者 并在24个月内招募至少50名符合条件的患者 句号。提供了建议的功能的文档 调查员及其工作人员对研究的表现符合 OHTS程序手册的细节、性质和范围 他们对Kresge眼科研究所的承诺，以及5名眼科医生的名单 在该地区谁将转介或跟踪接受登记筛选的患者 OHTS临床试验中的随机治疗。 首席调查员是一名训练有素、经验丰富的研究员 青光眼专科医生积极参与青光眼转诊实践。 Kresge眼科研究所，拟建的临床中心，这是一个 临床卓越中心和主要的眼科研究中心 底特律医疗中心和韦恩医院眼科 位于大底特律市区的州立大学医学院 拥有430万人口的大都市。首席调查员执行 每年约10,000例患者检查，约500例青光眼切开 手术过程中，约有700例青光眼激光手术。 首席研究员、他的临床研究员和住院医生也治疗 超过5,000名青光眼或高眼压患者在 Kresge眼科研究所青光眼住院医师诊所和退伍军人 行政医院眼科诊所。此外，校长 调查人员已经从他的病人中发现了75只眼 参加资格考试的高血压患者 根据这项研究的资格和排除标准对OHTS进行评估。 因此，首席调查员将很容易做到 Kresge眼科研究所将招收至少50名符合条件的眼科患者 高血压性青光眼怀疑，如有必要，更多，特别是与 5位合作者、其他社区眼科医生和 使用有效的招聘方法。

DESCRIPTION (Investigator's Abstract) This is an application to become a participating Clinical Center in the Ocular Hypertension Treatment Study (OHTS). The complete details of the OHTS rationale, design, and methods are contained in the OHTS Manual of Procedures. This proposal provides complete documentation of the ability of Kresge Eye Institute to screen large numbers of ocular hypertensive patients and to enroll at least 50 eligible patients over a 24-month period. Documentation is provided of the capabilities of the proposed investigator and his staff for the performance of the Study in accord with the details of the OHTS Manual of Procedures, the nature and extent of their commitment to Kresge Eye Institute, and a list of 5 ophthalmologists in the area who will refer or follow patients screened for enrollment and randomization to treatment in the OHTS clinical trial. The Principal Investigator is a fellowship trained and experienced glaucoma subspecialist actively engaged in a referral glaucoma practice at the Kresge Eye Institute, the proposed clinical center, which is a clinical center of excellence and a major eye research center as the Department of Ophthalmology for the Detroit Medical Center and the Wayne State University School of Medicine in the greater Detroit urban metropolis of 4.3 million people. The Principal Investigator performs annually about 10,000 patient examinations, about 500 incisional glaucoma surgical procedures, and about 700 glaucoma laser surgical procedures. The Principal Investigator, his clinical fellows, and residents also treat more than 5,000 patients with glaucoma or ocular hypertension at the Kresge Eye Institute residents' glaucoma clinic and the Veterans Administration Hospital Eye Clinic. In addition, the Principal Investigator has already identified from his patient population 75 ocular hypertensive patients who are candidates for the qualifying examinations of the OHTS based on the Study's eligibility and exclusion criteria. Therefore, it will be readily feasible for the Principal Investigator of the Kresge Eye Institute to enroll at least 50 eligible ocular hypertensive glaucoma suspects and if necessary many more especially with the help of the 5 collaborators, other community ophthalmologists, and with the use of effective recruitment methods.