Noncanonical glycogen metabolism and hepatocellular carcinoma

肝细胞癌是世界上最常见和最致命的癌症之一，由于有限的治疗选择和缺乏对有效分子靶点的了解。因此，迫切需要确定更有效的治疗策略来治疗肝细胞癌。新出现的证据表明糖原代谢的典型途径与肝细胞癌的发生和发展有关。然而，糖原代谢的非规范途径在肝细胞癌中的作用仍然是谜。本提案的目的是确定糖原代谢的非规范途径如何在各种小鼠模型中改变肝细胞癌。这些研究的完成将极大地促进我们对肝细胞癌中糖原代谢的理解，并可能揭示一种新的治疗肝细胞癌的替代方法，目前肝细胞癌的治疗方案有限。

Hepatocellular carcinoma is one of the most common and deadliest cancers in the world due to limited treatment options and lack of knowledge of effective molecular targets. Thus, there is an urgent need to identify more effective therapeutic strategies to treat hepatocellular carcinoma. Emerging evidence has shown that canonical routes of glycogen metabolism are linked to hepatocellular carcinoma initiation and progression. However, the role of non-canonical routes of glycogen metabolism in hepatocellular carcinoma remains enigmatic. The objective of this proposal is the define how targeting non-canonical routes of glycogen metabolism modifies hepatocellular carcinoma in various mouse models. Completion of the proposed studies will greatly advance our understanding of glycogen metabolism in the context of hepatocellular carcinoma and potentially reveal a novel alternative approach to treat hepatocellular carcinoma, for which there are currently limited treatment options for.