Contract Kick-off Meeting for NINDS Pharmacology and Toxicology for Therapeutics Program (PTTP)

本任务订单将涵盖啮齿动物的性能（例如，大鼠和小鼠）和非啮齿类动物（例如，犬、非人灵长类动物（NHP）、兔）对BPN产生的化合物的PK研究，每年一次，持续5年。 由于无法提前准确预测给定年份内需要进行的PK研究的实际数量，因此可以合理协商的最多是承包商在本任务订单的5年期间每年进行约6项啮齿类动物和2项非啮齿类动物药代动力学研究的相关人员和工作水平。 人们认识到，在给定年份，PK研究的实际数量和这些研究中的任务类型可能会因项目和评估化合物的需求而异。

This task order will cover the performance of rodent (e.g., rat and mouse) and non-rodent (e.g., dog, non-human primate (NHP), rabbit) PK studies of compounds generated by the BPN, on a yearly basis, for the next five (5) years. Since the actual number of PK studies that will be needed within a given year cannot be accurately predicted in advance, the most that can be fairly bargained for is for the Contractor to have available the personnel and level of effort associated with performing approximately 6 rodent and 2 non-rodent pharmacokinetic studies per year during the five-year period of this task order. It is recognized that the actual number of PK studies and types of tasks within these studies, in a given year, may vary based on the needs of the program and compound being assessed.