Administrative Core

摘要 核心A，行政核心，将为拟议的U19项目“基于遗传变异的药物发现”提供服务 以保守的衰老途径为目标“，由四个项目和一个研究资源核心(核心B)组成。 这两位PI是阿尔伯特·爱因斯坦医学院遗传学系主任Jan Vijg博士，以及 老龄化和DNA损伤修复专家保罗·罗宾斯博士，老龄化生物学研究所联席主任 他是明尼苏达大学细胞衰老和药物开发的专家， 和阿尔伯特·爱因斯坦医学院老龄化研究所所长尼尔·巴尔齐莱博士 老年学家招募老年人并对其进行表型鉴定，同时也是异常长寿的遗传学专家。这些 互补和协同的资历使Vijg、Robbins和Barzilai博士非常有资格共同执导这部电影 U19。已经确定了利用人类百岁老人的遗传学来识别基因和 作为促进人类健康潜在药物靶点的候选途径--更新的重点 应用程序将通过对我们自己和其他额外基因的整个外显子组分析来扩展程序 资源，进一步的基因功能化，开发更多的小鼠模型，并扩大我们的 候选干预措施。为了实现这些目标，我们提出了一种跨学科的方法，充分利用 细胞基因组学、高通量功能筛选、干细胞生物学、小鼠和 人类遗传学和药物筛选。行政核心的总体目标将是确保这一做法 通过提供一般的科学、方案和财政领导，有效地工作，促进 参与U19的不同研究人员之间的沟通，保持了U19的整体连贯，S 和长期目标，并确保研究产生的资源将造福科学界。 在上述背景下，该核心的任务包括有效协调四项研究的活动 项目和一个研究资源核心(核心B)。这应该促进和扩大有效利用 人类百岁老人队列获得对开发药物推广靶标至关重要的遗传信息 人类健康的广度，例如，通过增加复原力、动员新技术和工具来 帮助我们更快、更高效地完成任务，并为科学界提供访问 生产的资源、信息和技术。

ABSTRACT Core A, the Administrative Core, will serve the proposed U19 project “Genetic variant-based drug discovery targeting conserved pathways of aging”, comprised of four projects and one research resource Core (Core B). The PIs are Dr. Jan Vijg, Chairman of the Department of Genetics at the Albert Einstein College of Medicine, an expert in aging and DNA damage repair, Dr. Paul Robbins, Co-Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota, an expert in cellular senescence and drug development, and Dr. Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine, a geroscientist recruiting and phenotyping aging humans and expert in the genetics of exceptional longevity. These complementary and synergistic qualifications make Drs. Vijg, Robbins and Barzilai well-qualified to co-direct this U19. Having established the feasibility of using the genetics of human centenarians to identify genes and pathways as candidates for potential drug targets for promoting human healthspan, the focus of the renewal application will be to expand the program through whole exome analysis of our own and other, additional genetic resources, further gene functionalization, developing additional mouse models and expanding our pipeline of candidate interventions. To accomplish these goals, we propose an interdisciplinary approach, making full use of the latest advances in cellular genomics, high-throughput functional screening, stem cell biology, mouse and human genetics and drug screening. The overall goals of the Administrative Core will be to ensure this approach is working effectively by providing general scientific, programmatic and fiscal leadership, facilitate lines of communication between the different researchers involved in the U19, maintain coherence in the U19's overall and long-range goals, and ensure that resources resulting from the research will benefit the scientific community. In the context of the above, the tasks of this Core include effective coordination of activities by the four Research Projects and the one Research Resource Core (Core B). This should promote and expand the effective use of the human centenarian cohorts to obtain genetic information critical for developing targets for drugs promoting human healthspan, for example, by increasing resilience, the mobilization of new technology and tools that can help us accomplish our tasks more quickly and efficiently and providing access by the scientific community to the resources, information and technologies produced.