Administrative Core

项目摘要/摘要 行政核心负责管理所有项目和核心资源，并确保合规 符合所有政府和具体的NIH法规和要求，包括及时沟通和 咨询项目办公室和NCI的其他工作人员。核心小组将召开所有必要会议，包括 内部过度指导委员会每月会议和外部科学咨询年度会议 委员会审议阶段。具体目标是：具体目标1.维护和进一步开发一个数据库，以 流行病学、遗传学和生物标记物数据。这座山。多伦多的西奈集团协调了来自80个国家的数据 研究包括125,000名肺癌患者和100多万名队列个人。是否可以使用 这一面向计划项目负责人的资源使提议的项目能够快速、高效和 有效地。具体目标2.为计划项目活动提供综合支持。一项主要职能 这一核心是确保方案项目关系和沟通的有效运作。 为沟通提供支持的是制定明确的沟通指导方针和权威、程序 提出新项目，定期召开电话会议，维护收集和管理的网站 所有会议的结果。具体目标3.制定和评估不同研究结果的翻译 人口。一个专注于实施科学的新组成部分将由圣彼得堡的华盛顿大学领导。 路易。该组件利用其实施科学核心来支持评估影响的项目 个人化评估和吸烟对肺癌风险的影响及其缓解的信息， 对少数民族人口的重视。核心组件还使用定性研究核心，网址为 范德比尔特大学医学中心在针对不同社区开展焦点小组方面提供建议， 包括在评估基因组风险和最不发达国家研究中通常得不到充分服务的少数群体 筛选计划。具体目标4.确保计划项目符合所有法规 要求。管理核心支持支持研究的协议的开发。它 协调与DBGaP和其他需要数据传输的实体的关系。它还将设法 与NCI计划、技术和行政人员的所有沟通。行政核心还 监督财务管理，确保及时管理项目之间的财务关系 和核心。行政核心在支持调查员互动和确保 完成目标。P01版本的管理来自我们的团队领导的成功完成的研究 跨分布式网络的调查人员，由清晰的通信和广泛的 文件。

Project Summary/Abstract The Administrative Core is responsible for managing all project and core resources and ensuring compliance with all governmental and specific NIH regulations and requirements, including timely communication and consultation with project offices and other NCI staff. The core will convene all necessary meetings, including monthly meetings of the internal oversteering committee and annual meeting of the external scientific advisory committee. The specific aims are: Specific Aim 1. Maintain and further develop a database for epidemiological, genetic and biomarker data. The Mt. Sinai group in Toronto has harmonized data from 80 studies comprising 125,000 lung cancer patients and more than 1 million cohort individuals. The availability of this resource for Program Project leaders allows the proposed projects to be launched rapidly, efficiently and effectively. Specific Aim 2. Provide Integrative Support for Program Project Activities. A primary function of this core is to ensure the efficient functioning of Program Project relationships and communication. Communication is supported by development of clear guidelines of communication and authority, procedures for proposing new projects, regular teleconference calls, and maintenance of a website that collects and manages results from all meetings. Specific Aim 3. Develop and evaluate the translation of findings in diverse populations. A new component focusing on implementation science will be led by Washington University in St. Louis. This component leverages their implementation science core to support projects that assess the impacts of personalized evaluation and of messaging of smoking’s impact upon lung cancer risks and its mitigation, with an emphasis on minority populations. The core component also uses the Qualitative Research Core available at the Vanderbilt University Medical Center to advice in conducting focus groups targeting different communities, including minority populations that are typically underserved, in evaluating genomic risk and in the LDCT screening program.Specific Aim 4. Ensure compliance of the Program Project with all Regulatory Requirements. The administrative core supports the development of protocols that support studies. It coordinates relationships with dbGAP and other entities for whom data transfers are required. It will also manage all communications with NCI programmatic, technical and administrative staff. The administrative core also oversees financial management and ensures timely management of financial relationships among the Projects and Cores. The administrative core plays a central role in supporting investigator interactions and ensuring completion of aims. Administration for the P01 builds from successfully completed studies led by our teams of investigators across a distributed network that is managed by clear communications and extensive documentation.