Mediation pathways for the receptor for advanced glycation end products in diabetic nephropathy

糖尿病患者血液中过量的糖分是有害的，会加速糖分附着在蛋白质、脂肪和DNA上的过程。虽然高糖促进了反应，但在低糖和高水平氧自由基存在的情况下，反应会愉快地发生。这些复合体被称为晚期糖基化终末产物或AGEs。此外，我们从饮食中摄取了大量的AGE，这些AGE被吸收到血液中。众所周知，这些AGE与糖尿病受试者肾脏疾病的发生有关。AGEs通过与特定的蛋白质结合来发挥其对身体的大部分作用，其中最常见和最有害的是晚期糖基化终末产物的受体RAGE。RAGE是已知的其他严重疾病的参与者，如阿尔茨海默病，越来越多的证据表明它在糖尿病受试者肾脏疾病的发展中发挥核心作用。人们对调解愤怒的过程知之甚少，这就是为什么这是这项提议的目的。这将使我们能够阻止糖尿病患者肾脏疾病的无情发展。

Excess sugar in the blood from diabetes is detrimental and can accelerate a process where sugar attaches itself to proteins, fats and DNA. Although facilitated by high sugar, the reaction occurs happily in the presence of low sugar with high levels of free oxygen radicals. These complexes are called advanced glycation end products or AGEs. In addition, we ingest vast volumes of AGES from our diet which are taken into the blood. These AGEs are known to be involved in the development of kidney disease in diabetic subjects. AGEs exert most of their effects on the body by binding to specific proteins, the most common and nasty of which is the receptor for advanced glycation end products, RAGE. RAGE is a known participant in other serious diseases such as Alzheimer's disease and evidence is mounting for its central role in the development of kidney disease in diabetic subjects. There is not much known about the processes which mediate RAGE which is why this is the aim of this proposal. This will enable us to stop the relentless progression of kidney disease in diabetes.